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Page 1
Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.
Agard NJ, Zhang G, Ridgeway J, Dicara DM, Chu PY, Ohri R, Sanowar S, Vernes JM, Chi H, Zhang J, Holz E, Paluch M, He G, Benson Y, Zhang J, Chan P, Tang N, Javale P, Wilson B, Barrett K, Rowntree RK, Hang J, Meng YG, Hass P, Fuh G, Piskol R, Bantseev V, Loyet KM, Tran JC, Wu C, Indjeian VB, Shivva V, Yan M. Agard NJ, et al. Transl Vis Sci Technol. 2022 Oct 3;11(10):27. doi: 10.1167/tvst.11.10.27. Transl Vis Sci Technol. 2022. PMID: 36255358 Free PMC article.
Targeted IgMs agonize ocular targets with extended vitreal exposure.
Chen Y, Paluch M, Zorn JA, Rajan S, Leonard B, Estevez A, Brady J, Chiu H, Phung W, Famili A, Yan M, Ciferri C, Matsumoto ML, Lazar GA, Crowell S, Hass P, Agard NJ. Chen Y, et al. Among authors: agard nj. MAbs. 2020 Jan-Dec;12(1):1818436. doi: 10.1080/19420862.2020.1818436. MAbs. 2020. PMID: 32936727 Free PMC article.
Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Dela Cruz Chuh J, Go M, Chen Y, Guo J, Rafidi H, Mandikian D, Sun Y, Lin Z, Schneider K, Zhang P, Vij R, Sharpnack D, Chan P, de la Cruz C, Sadowsky J, Seshasayee D, Koerber JT, Pillow TH, Phillips GD, Rowntree RK, Boswell CA, Kozak KR, Polson AG, Polakis P, Yu SF, Dragovich PS, Agard NJ. Dela Cruz Chuh J, et al. Among authors: agard nj. MAbs. 2021 Jan-Dec;13(1):1862452. doi: 10.1080/19420862.2020.1862452. MAbs. 2021. PMID: 33382956 Free PMC article.
Translatability of In Vitro Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Chu PY, Wang H, Ross E, Stephens N, Zhang HM, Andersen N, Chan W, Shivva V, Crowell SR, Spiess C, Holder PG, Agard NJ, Ji C, Chen J, Sreedhara A, Wang J, Wu C, Liu Y, Tran JC. Chu PY, et al. Among authors: agard nj. Anal Chem. 2023 Dec 12;95(49):17957-17961. doi: 10.1021/acs.analchem.3c02133. Epub 2023 Nov 30. Anal Chem. 2023. PMID: 38084380
Exposing the molecular heterogeneity of glycosylated biotherapeutics.
Schachner LF, Mullen C, Phung W, Hinkle JD, Beardsley MI, Bentley T, Day P, Tsai C, Sukumaran S, Baginski T, DiCara D, Agard NJ, Masureel M, Gober J, ElSohly AM, Melani R, Syka JEP, Huguet R, Marty MT, Sandoval W. Schachner LF, et al. Among authors: agard nj. Nat Commun. 2024 Apr 16;15(1):3259. doi: 10.1038/s41467-024-47693-8. Nat Commun. 2024. PMID: 38627419 Free PMC article.
Unraveling the mechanism of cell death induced by chemical fibrils.
Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Julien O, et al. Among authors: agard nj. Nat Chem Biol. 2014 Nov;10(11):969-76. doi: 10.1038/nchembio.1639. Epub 2014 Sep 28. Nat Chem Biol. 2014. PMID: 25262416 Free PMC article.
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