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Page 1
Cardiovascular concentration-effect relationships of amodiaquine and its metabolite desethylamodiaquine: Clinical and preclinical studies.
Chan XHS, Chotsiri P, Capel RA, Pike J, Hanboonkunupakarn B, Lee SJ, Hanafiah M, Win YN, Cremer MA, Kiechel JR, Ogutu B, Taylor WRJ, Burton RB, Tarning J, White NJ. Chan XHS, et al. Among authors: ogutu b. Br J Clin Pharmacol. 2023 Mar;89(3):1176-1186. doi: 10.1111/bcp.15569. Epub 2022 Nov 8. Br J Clin Pharmacol. 2023. PMID: 36256474 Free PMC article.
Population pharmacokinetics and pharmacodynamic considerations of amodiaquine and desethylamodiaquine in Kenyan adults with uncomplicated malaria receiving artesunate-amodiaquine combination therapy.
Jullien V, Ogutu B, Juma E, Carn G, Obonyo C, Kiechel JR. Jullien V, et al. Among authors: ogutu b. Antimicrob Agents Chemother. 2010 Jun;54(6):2611-7. doi: 10.1128/AAC.01496-09. Epub 2010 Apr 5. Antimicrob Agents Chemother. 2010. PMID: 20368402 Free PMC article. Clinical Trial.
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data.
WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group; Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Brasseur P, Bukirwa H, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Desai M, Diap G, Djimde AA, Dorsey G, Doumbo OK, Espié E, Etard JF, Fanello CI, Faucher JF, Faye B, Flegg JA, Gaye O, Gething PW, González R, Grandesso F, Guerin PJ, Guthmann JP, Hamour S, Hasugian AR, Hay SI, Humphreys GS, Jullien V, Juma E, Kamya MR, Karema C, Kiechel JR, Kremsner PG, Krishna S, Lameyre V, Ibrahim LM, Lee SJ, Lell B, Mårtensson A, Massougbodji A, Menan H, Ménard D, Menéndez C, Meremikwu M, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Nikiema F, Nsanzabana C, Ntoumi F, Ogutu BR, Olliaro P, Osorio L, Ouédraogo JB, Penali LK, Pene M, Pinoges L, Piola P, Price RN, Roper C, Rosenthal PJ, Rwagacondo CE, Same-Ekobo A, Schramm B, Seck A, Sharma B, Sibley CH, Sinou V, Sirima SB, Smith JJ, Smithuis F, Somé FA, Sow D, Staedke SG, Stepniewska K, Swarthout TD, Sylla K, Talisuna AO, Tarning J, Taylor WR, Temu EA, Thwing JI, Tjitra E, Tine RC, Tinto H, Vaillant MT, Valecha N, Van den Broek … See abstract for full author list ➔ WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, et al. Among authors: ogutu br. BMC Med. 2015 Mar 31;13:66. doi: 10.1186/s12916-015-0301-z. BMC Med. 2015. PMID: 25888957 Free PMC article.
Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data.
WWARN Artemisinin based Combination Therapy (ACT) Africa Baseline Study Group; Dahal P, d'Alessandro U, Dorsey G, Guerin PJ, Nsanzabana C, Price RN, Sibley CH, Stepniewska K, Talisuna AO. WWARN Artemisinin based Combination Therapy (ACT) Africa Baseline Study Group, et al. BMC Med. 2015 Sep 7;13:212. doi: 10.1186/s12916-015-0445-x. BMC Med. 2015. PMID: 26343145 Free PMC article. Review.
Pooled Multicenter Analysis of Cardiovascular Safety and Population Pharmacokinetic Properties of Piperaquine in African Patients with Uncomplicated Falciparum Malaria.
Wattanakul T, Ogutu B, Kabanywanyi AM, Asante KP, Oduro A, Adjei A, Sie A, Sevene E, Macete E, Compaore G, Valea I, Osei I, Winterberg M, Gyapong M, Adjuik M, Abdulla S, Owusu-Agyei S, White NJ, Day NPJ, Tinto H, Baiden R, Binka F, Tarning J. Wattanakul T, et al. Among authors: ogutu b. Antimicrob Agents Chemother. 2020 Jun 23;64(7):e01848-19. doi: 10.1128/AAC.01848-19. Print 2020 Jun 23. Antimicrob Agents Chemother. 2020. PMID: 32312783 Free PMC article.
Pregnancy outcomes and risk of placental malaria after artemisinin-based and quinine-based treatment for uncomplicated falciparum malaria in pregnancy: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis.
Saito M, Mansoor R, Kennon K, Anvikar AR, Ashley EA, Chandramohan D, Cohee LM, D'Alessandro U, Genton B, Gilder ME, Juma E, Kalilani-Phiri L, Kuepfer I, Laufer MK, Lwin KM, Meshnick SR, Mosha D, Muehlenbachs A, Mwapasa V, Mwebaza N, Nambozi M, Ndiaye JA, Nosten F, Nyunt M, Ogutu B, Parikh S, Paw MK, Phyo AP, Pimanpanarak M, Piola P, Rijken MJ, Sriprawat K, Tagbor HK, Tarning J, Tinto H, Valéa I, Valecha N, White NJ, Wiladphaingern J, Stepniewska K, McGready R, Guérin PJ. Saito M, et al. Among authors: ogutu b. BMC Med. 2020 Jun 2;18(1):138. doi: 10.1186/s12916-020-01592-z. BMC Med. 2020. PMID: 32482173 Free PMC article.
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Saito M, Mansoor R, Kennon K, Anvikar AR, Ashley EA, Chandramohan D, Cohee LM, D'Alessandro U, Genton B, Gilder ME, Juma E, Kalilani-Phiri L, Kuepfer I, Laufer MK, Lwin KM, Meshnick SR, Mosha D, Mwapasa V, Mwebaza N, Nambozi M, Ndiaye JA, Nosten F, Nyunt M, Ogutu B, Parikh S, Paw MK, Phyo AP, Pimanpanarak M, Piola P, Rijken MJ, Sriprawat K, Tagbor HK, Tarning J, Tinto H, Valéa I, Valecha N, White NJ, Wiladphaingern J, Stepniewska K, McGready R, Guérin PJ. Saito M, et al. Among authors: ogutu b. Lancet Infect Dis. 2020 Aug;20(8):943-952. doi: 10.1016/S1473-3099(20)30064-5. Epub 2020 Apr 29. Lancet Infect Dis. 2020. PMID: 32530424 Free PMC article.
The cardiovascular effects of amodiaquine and structurally related antimalarials: An individual patient data meta-analysis.
Chan XHS, Haeusler IL, Win YN, Pike J, Hanboonkunupakarn B, Hanafiah M, Lee SJ, Djimdé A, Fanello CI, Kiechel JR, Lacerda MV, Ogutu B, Onyamboko MA, Siqueira AM, Ashley EA, Taylor WR, White NJ. Chan XHS, et al. Among authors: ogutu b. PLoS Med. 2021 Sep 7;18(9):e1003766. doi: 10.1371/journal.pmed.1003766. eCollection 2021 Sep. PLoS Med. 2021. PMID: 34492005 Free PMC article.
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