McDonald JG - Search Results

1

Loss of heat shock factor initiates intracellular lipid surveillance by actin destabilization.

Watterson A, Arneaud SLB, Wajahat N, Wall JM, Tatge L, Beheshti ST, Mihelakis M, Cheatwood NY, McClendon J, Ghorashi A, Dehghan I, Corley CD, McDonald JG, Douglas PM. Watterson A, et al. Among authors: mcdonald jg. Cell Rep. 2022 Oct 18;41(3):111493. doi: 10.1016/j.celrep.2022.111493. Cell Rep. 2022. PMID: 36261024 Free PMC article.

2

Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis.

Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, McDonald J, Wistuba II, DeBerardinis RJ, Scaglioni PP. Padanad MS, et al. Cell Rep. 2016 Aug 9;16(6):1614-1628. doi: 10.1016/j.celrep.2016.07.009. Epub 2016 Jul 28. Cell Rep. 2016. PMID: 27477280 Free PMC article.

3

Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency.

Evers BM, Rodriguez-Navas C, Tesla RJ, Prange-Kiel J, Wasser CR, Yoo KS, McDonald J, Cenik B, Ravenscroft TA, Plattner F, Rademakers R, Yu G, White CL 3rd, Herz J. Evers BM, et al. Cell Rep. 2017 Sep 12;20(11):2565-2574. doi: 10.1016/j.celrep.2017.08.056. Cell Rep. 2017. PMID: 28903038 Free PMC article.

4

Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.

Sharma AX, Quittner-Strom EB, Lee Y, Johnson JA, Martin SA, Yu X, Li J, Lu J, Cai Z, Chen S, Wang MY, Zhang Y, Pearson MJ, Dorn AC, McDonald JG, Gordillo R, Yan H, Thai D, Wang ZV, Unger RH, Holland WL. Sharma AX, et al. Among authors: mcdonald jg. Cell Rep. 2018 Feb 13;22(7):1760-1773. doi: 10.1016/j.celrep.2018.01.065. Cell Rep. 2018. PMID: 29444429 Free PMC article.

5

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease.

Datta S, Bowerman J, Hariri H, Ugrankar R, Eckert KM, Corley C, Vale G, McDonald JG, Henne WM. Datta S, et al. Among authors: mcdonald jg. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33282-33294. doi: 10.1073/pnas.2011124117. Epub 2020 Dec 11. Proc Natl Acad Sci U S A. 2020. PMID: 33310904 Free PMC article.

6

Intracellular lipid surveillance by small G protein geranylgeranylation.

Watterson A, Tatge L, Wajahat N, Arneaud SLB, Solano Fonseca R, Beheshti ST, Metang P, Mihelakis M, Zuurbier KR, Corley CD, Dehghan I, McDonald JG, Douglas PM. Watterson A, et al. Among authors: mcdonald jg. Nature. 2022 May;605(7911):736-740. doi: 10.1038/s41586-022-04729-7. Epub 2022 May 18. Nature. 2022. PMID: 35585236 Free PMC article.

7

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells.

Luo M, Bao L, Chen Y, Xue Y, Wang Y, Zhang B, Wang C, Corley CD, McDonald JG, Kumar A, Xing C, Fang Y, Nelson ER, Wang JE, Wang Y, Luo W. Luo M, et al. Among authors: mcdonald jg. Sci Adv. 2022 Jul 15;8(28):eabn5295. doi: 10.1126/sciadv.abn5295. Epub 2022 Jul 15. Sci Adv. 2022. PMID: 35857506 Free PMC article.

8

A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection.

Heisler DB, Johnson KA, Ma DH, Ohlson MB, Zhang L, Tran M, Corley CD, Abrams ME, McDonald JG, Schoggins JW, Alto NM, Radhakrishnan A. Heisler DB, et al. Among authors: mcdonald jg. Elife. 2023 Jan 25;12:e83534. doi: 10.7554/eLife.83534. Elife. 2023. PMID: 36695568 Free PMC article.

9

Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production.

Nguyen TP, Wang W, Sternisha AC, Corley CD, Wang HL, Wang X, Ortiz F, Lim SK, Abdullah KG, Parada LF, Williams NS, McBrayer SK, McDonald JG, De Brabander JK, Nijhawan D. Nguyen TP, et al. Among authors: mcdonald jg. Cell Chem Biol. 2023 Feb 16;30(2):214-229.e18. doi: 10.1016/j.chembiol.2023.01.005. Epub 2023 Feb 8. Cell Chem Biol. 2023. PMID: 36758549 Free PMC article.

10

Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.

Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH. Chen H, et al. Among authors: mcdonald jg. Cell. 2023 Jun 8;186(12):2644-2655.e16. doi: 10.1016/j.cell.2023.04.028. Epub 2023 May 23. Cell. 2023. PMID: 37224812 Free PMC article.

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