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A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression.
Takase S, Hiroyama T, Shirai F, Maemoto Y, Nakata A, Arata M, Matsuoka S, Sonoda T, Niwa H, Sato S, Umehara T, Shirouzu M, Nishigaya Y, Sumiya T, Hashimoto N, Namie R, Usui M, Ohishi T, Ohba SI, Kawada M, Hayashi Y, Harada H, Yamaguchi T, Shinkai Y, Nakamura Y, Yoshida M, Ito A. Takase S, et al. Nat Commun. 2023 Jan 12;14(1):23. doi: 10.1038/s41467-022-35404-0. Nat Commun. 2023. PMID: 36635268 Free PMC article.
Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment.
Nishigaya Y, Takase S, Sumiya T, Sato T, Niwa H, Sato S, Nakata A, Matsuoka S, Maemoto Y, Hashimoto N, Namie R, Honma T, Umehara T, Shirouzu M, Koyama H, Yoshida M, Ito A, Shirai F. Nishigaya Y, et al. Among authors: takase s. Bioorg Med Chem Lett. 2024 Sep 15;110:129856. doi: 10.1016/j.bmcl.2024.129856. Epub 2024 Jun 22. Bioorg Med Chem Lett. 2024. PMID: 38914346
Allylic hydroxylation of triterpenoids by a plant cytochrome P450 triggers key chemical transformations that produce a variety of bitter compounds.
Takase S, Kera K, Nagashima Y, Mannen K, Hosouchi T, Shinpo S, Kawashima M, Kotake Y, Yamada H, Saga Y, Otaka J, Araya H, Kotera M, Suzuki H, Kushiro T. Takase S, et al. J Biol Chem. 2019 Dec 6;294(49):18662-18673. doi: 10.1074/jbc.RA119.009944. Epub 2019 Oct 27. J Biol Chem. 2019. PMID: 31656227 Free PMC article.
635 results