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Page 1
Tumor-associated macrophages expressing the transcription factor IRF8 promote T cell exhaustion in cancer.
Nixon BG, Kuo F, Ji L, Liu M, Capistrano K, Do M, Franklin RA, Wu X, Kansler ER, Srivastava RM, Purohit TA, Sanchez A, Vuong L, Krishna C, Wang X, Morse Iii HC, Hsieh JJ, Chan TA, Murphy KM, Moon JJ, Hakimi AA, Li MO. Nixon BG, et al. Among authors: purohit ta. Immunity. 2022 Nov 8;55(11):2044-2058.e5. doi: 10.1016/j.immuni.2022.10.002. Epub 2022 Oct 25. Immunity. 2022. PMID: 36288724 Free PMC article.
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy.
Krishna C, DiNatale RG, Kuo F, Srivastava RM, Vuong L, Chowell D, Gupta S, Vanderbilt C, Purohit TA, Liu M, Kansler E, Nixon BG, Chen YB, Makarov V, Blum KA, Attalla K, Weng S, Salmans ML, Golkaram M, Liu L, Zhang S, Vijayaraghavan R, Pawlowski T, Reuter V, Carlo MI, Voss MH, Coleman J, Russo P, Motzer RJ, Li MO, Leslie CS, Chan TA, Hakimi AA. Krishna C, et al. Among authors: purohit ta. Cancer Cell. 2021 May 10;39(5):662-677.e6. doi: 10.1016/j.ccell.2021.03.007. Epub 2021 Apr 15. Cancer Cell. 2021. PMID: 33861994 Free PMC article.
Diverse Neoantigens and the Development of Cancer Therapies.
Srivastava RM, Purohit TA, Chan TA. Srivastava RM, et al. Among authors: purohit ta. Semin Radiat Oncol. 2020 Apr;30(2):113-128. doi: 10.1016/j.semradonc.2019.12.001. Semin Radiat Oncol. 2020. PMID: 32381291 Review.
Mutations in BRCA1 and BRCA2 differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy.
Samstein RM, Krishna C, Ma X, Pei X, Lee KW, Makarov V, Kuo F, Chung J, Srivastava RM, Purohit TA, Hoen DR, Mandal R, Setton J, Wu W, Shah R, Qeriqi B, Chang Q, Kendall S, Braunstein L, Weigelt B, Blecua Carrillo Albornoz P, Morris LGT, Mandelker DL, Reis-Filho JS, de Stanchina E, Powell SN, Chan TA, Riaz N. Samstein RM, et al. Among authors: purohit ta. Nat Cancer. 2021 Dec;1(12):1188-1203. doi: 10.1038/s43018-020-00139-8. Epub 2020 Nov 16. Nat Cancer. 2021. PMID: 33834176 Free PMC article.
Commensal bacteria stimulate antitumor responses via T cell cross-reactivity.
Bessell CA, Isser A, Havel JJ, Lee S, Bell DR, Hickey JW, Chaisawangwong W, Glick Bieler J, Srivastava R, Kuo F, Purohit T, Zhou R, Chan TA, Schneck JP. Bessell CA, et al. Among authors: purohit t. JCI Insight. 2020 Apr 23;5(8):e135597. doi: 10.1172/jci.insight.135597. JCI Insight. 2020. PMID: 32324171 Free PMC article.