Chan TH - Search Results

1

Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)₂, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2).

Chong TC, Wong ILK, Cui J, Law MC, Zhu X, Hu X, Kan JWY, Yan CSW, Chan TH, Chow LMC. Chong TC, et al. Among authors: chan th. Int J Mol Sci. 2022 Oct 31;23(21):13261. doi: 10.3390/ijms232113261. Int J Mol Sci. 2022. PMID: 36362047 Free PMC article.

2

Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel.

Kan JWY, Yan CSW, Wong ILK, Su X, Liu Z, Chan TH, Chow LMC. Kan JWY, et al. Among authors: chan th. Int J Mol Sci. 2022 Dec 4;23(23):15299. doi: 10.3390/ijms232315299. Int J Mol Sci. 2022. PMID: 36499627 Free PMC article.

3

In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31.

Sun W, Wong ILK, Law HK, Su X, Chan TCF, Sun G, Yang X, Wang X, Chan TH, Wan S, Chow LMC. Sun W, et al. Among authors: chan th, chan tcf. Int J Mol Sci. 2023 Feb 22;24(5):4377. doi: 10.3390/ijms24054377. Int J Mol Sci. 2023. PMID: 36901808 Free PMC article.

4

Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid FM04.

Liu Z, Wong ILK, Sang J, Liu F, Yan CSW, Kan JWY, Chan TH, Chow LMC. Liu Z, et al. Among authors: chan th. J Med Chem. 2023 May 11;66(9):6160-6183. doi: 10.1021/acs.jmedchem.2c02005. Epub 2023 Apr 25. J Med Chem. 2023. PMID: 37098275

5

Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety.

Surur AS, Chan CF, Bartz FM, Wong ILK, Nguyen VTD, Schulig L, Link A, Chan TH, Chow LMC, Bednarski PJ. Surur AS, et al. Among authors: chan th. RSC Med Chem. 2024 Aug 30;15(11):3837-52. doi: 10.1039/d4md00426d. Online ahead of print. RSC Med Chem. 2024. PMID: 39297060 Free article.

6

Tetrazepinones are equally cytotoxic to Mer+ and Mer- human tumor cell lines.

Jean-Claude BJ, Mustafa A, Watson AJ, Damian Z, Vasilescu D, Chan TH, Leyland-Jones B. Jean-Claude BJ, et al. Among authors: chan th. J Pharmacol Exp Ther. 1999 Feb;288(2):484-9. J Pharmacol Exp Ther. 1999. PMID: 9918549

7

Cytokinetics of a novel 1,2,3-triazene-containing heterocycle, 8-nitro-3-methyl-benzo-1,2,3,5-tetrazepin-4(3H)-one (NIME), in the human epithelial ovarian cancer cell line OVCAR-3.

Jean-Claude BJ, Mustafa A, Damian Z, De Marte J, Vasilescu DE, Yen R, Chan TH, Leyland-Jones B. Jean-Claude BJ, et al. Among authors: chan th. Biochem Pharmacol. 1999 Apr 1;57(7):753-62. doi: 10.1016/s0006-2952(98)00345-1. Biochem Pharmacol. 1999. PMID: 10075081

8

(-)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro.

Wong KC, Cao S, Dong X, Law MC, Chan TH, Wong MS. Wong KC, et al. Among authors: chan th. Nutrients. 2017 May 22;9(5):530. doi: 10.3390/nu9050530. Nutrients. 2017. PMID: 28531166 Free PMC article.

9

Design and mechanism of action of a novel cytotoxic 1,2,3-triazene-containing heterocycle, 3,5-dimethyl-pyrido-1,2,3,5-tetrazepin-4-one (PYRZ), in the human epithelial ovarian cancer cell line NIH:OVCAR-3 in vitro.

Jean-Claude BJ, Mustafa A, Cetateanu ND, Damian Z, De Marte J, Yen R, Vasilescu D, Chan TH, Leyland-Jones B. Jean-Claude BJ, et al. Among authors: chan th. Br J Cancer. 1997;76(4):467-73. doi: 10.1038/bjc.1997.411. Br J Cancer. 1997. PMID: 9275023 Free PMC article.

10

Determination of (-)-epigallocatechin-3-gallate octaacetate and its metabolites in plasma of rats for pharmacokinetic study by ultra-performance-liquid-chromatography coupled to quadrupole-time-of-flight-mass-spectrometry.

Chu KO, Man GCW, Hung SW, Chan TH, Lee WYT, Chan KP, Pang CP, Wang CC. Chu KO, et al. Among authors: chan th, chan kp. Front Pharmacol. 2022 Oct 11;13:1025053. doi: 10.3389/fphar.2022.1025053. eCollection 2022. Front Pharmacol. 2022. PMID: 36304154 Free PMC article.

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