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M1 muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease.
Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn J, Lindsley CW, Bradley SJ, Tobin AB. Dwomoh L, et al. Among authors: christopoulos a. Sci Signal. 2022 Nov 15;15(760):eabm3720. doi: 10.1126/scisignal.abm3720. Epub 2022 Nov 15. Sci Signal. 2022. PMID: 36378750 Free PMC article.
Novel receptor partners and function of receptor activity-modifying proteins.
Christopoulos A, Christopoulos G, Morfis M, Udawela M, Laburthe M, Couvineau A, Kuwasako K, Tilakaratne N, Sexton PM. Christopoulos A, et al. Among authors: christopoulos g. J Biol Chem. 2003 Jan 31;278(5):3293-7. doi: 10.1074/jbc.C200629200. Epub 2002 Nov 21. J Biol Chem. 2003. PMID: 12446722 Free article.
RAMPs: 5 years on, where to now?
Morfis M, Christopoulos A, Sexton PM. Morfis M, et al. Among authors: christopoulos a. Trends Pharmacol Sci. 2003 Nov;24(11):596-601. doi: 10.1016/j.tips.2003.09.001. Trends Pharmacol Sci. 2003. PMID: 14607083 Review.
Allosteric modulation of G protein-coupled receptors.
May LT, Avlani VA, Sexton PM, Christopoulos A. May LT, et al. Among authors: christopoulos a. Curr Pharm Des. 2004;10(17):2003-13. doi: 10.2174/1381612043384303. Curr Pharm Des. 2004. PMID: 15279541 Review.
445 results