Leone RD - Search Results

1

Discovery of DRP-104, a tumor-targeted metabolic inhibitor prodrug.

Rais R, Lemberg KM, Tenora L, Arwood ML, Pal A, Alt J, Wu Y, Lam J, Aguilar JMH, Zhao L, Peters DE, Tallon C, Pandey R, Thomas AG, Dash RP, Seiwert T, Majer P, Leone RD, Powell JD, Slusher BS. Rais R, et al. Among authors: leone rd. Sci Adv. 2022 Nov 18;8(46):eabq5925. doi: 10.1126/sciadv.abq5925. Epub 2022 Nov 16. Sci Adv. 2022. PMID: 36383674 Free PMC article.

2

Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy.

Leone RD, Horton MR, Powell JD. Leone RD, et al. Cancer Cell. 2015 Apr 13;27(4):435-6. doi: 10.1016/j.ccell.2015.03.014. Cancer Cell. 2015. PMID: 25873169 Free PMC article.

3

A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy.

Leone RD, Lo YC, Powell JD. Leone RD, et al. Comput Struct Biotechnol J. 2015 Apr 8;13:265-72. doi: 10.1016/j.csbj.2015.03.008. eCollection 2015. Comput Struct Biotechnol J. 2015. PMID: 25941561 Free PMC article. Review.

4

Inhibition of the adenosine A2a receptor modulates expression of T cell coinhibitory receptors and improves effector function for enhanced checkpoint blockade and ACT in murine cancer models.

Leone RD, Sun IM, Oh MH, Sun IH, Wen J, Englert J, Powell JD. Leone RD, et al. Cancer Immunol Immunother. 2018 Aug;67(8):1271-1284. doi: 10.1007/s00262-018-2186-0. Epub 2018 Jun 19. Cancer Immunol Immunother. 2018. PMID: 29923026 Free PMC article.

5

Targeting metabolism to regulate immune responses in autoimmunity and cancer.

Patel CH, Leone RD, Horton MR, Powell JD. Patel CH, et al. Among authors: leone rd. Nat Rev Drug Discov. 2019 Sep;18(9):669-688. doi: 10.1038/s41573-019-0032-5. Epub 2019 Jul 30. Nat Rev Drug Discov. 2019. PMID: 31363227 Review.

6

Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion.

Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, Tam A, Blosser RL, Prchalova E, Alt J, Rais R, Slusher BS, Powell JD. Leone RD, et al. Science. 2019 Nov 22;366(6468):1013-1021. doi: 10.1126/science.aav2588. Epub 2019 Nov 7. Science. 2019. PMID: 31699883 Free PMC article.

7

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells.

Oh MH, Sun IH, Zhao L, Leone RD, Sun IM, Xu W, Collins SL, Tam AJ, Blosser RL, Patel CH, Englert JM, Arwood ML, Wen J, Chan-Li Y, Tenora L, Majer P, Rais R, Slusher BS, Horton MR, Powell JD. Oh MH, et al. Among authors: leone rd. J Clin Invest. 2020 Jul 1;130(7):3865-3884. doi: 10.1172/JCI131859. J Clin Invest. 2020. PMID: 32324593 Free PMC article.

8

Metabolism of immune cells in cancer.

Leone RD, Powell JD. Leone RD, et al. Nat Rev Cancer. 2020 Sep;20(9):516-531. doi: 10.1038/s41568-020-0273-y. Epub 2020 Jul 6. Nat Rev Cancer. 2020. PMID: 32632251 Free PMC article. Review.

9

Fueling the Revolution: Targeting Metabolism to Enhance Immunotherapy.

Leone RD, Powell JD. Leone RD, et al. Cancer Immunol Res. 2021 Mar;9(3):255-260. doi: 10.1158/2326-6066.CIR-20-0791. Cancer Immunol Res. 2021. PMID: 33648947 Free PMC article. Review.

10

Interrogation of T Cell-Enriched Tumors Reveals Prognostic and Immunotherapeutic Implications of Polyamine Metabolism.

Harbison RA, Pandey R, Considine M, Leone RD, Murray-Stewart T, Erbe R, Mandal R, Burns M, Casero RA Jr, Seiwert T, Fakhry C, Pardoll D, Fertig E, Powell JD. Harbison RA, et al. Among authors: leone rd. Cancer Res Commun. 2022 Jul;2(7):639-652. doi: 10.1158/2767-9764.crc-22-0061. Epub 2022 Jul 13. Cancer Res Commun. 2022. PMID: 36052016 Free PMC article.

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