Tillekeratne LMV - Search Results

1

Leveraging multi-mode microextraction and liquid chromatography stationary phases for quantitative analysis of neurotoxin β-N-methylamino-L-alanine and other non-proteinogenic amino acids.

Emmons RV, Karaj E, Cudjoe E, Bell DS, Tillekeratne LMV, Gionfriddo E. Emmons RV, et al. Among authors: tillekeratne lmv. J Chromatogr A. 2022 Dec 6;1685:463636. doi: 10.1016/j.chroma.2022.463636. Epub 2022 Nov 8. J Chromatogr A. 2022. PMID: 36401913

2

Mutant p53 reactivators protect breast cancer cells from ferroptosis.

Rathnayake DS, Dlamini S, Elkalawozgy K, Tillekeratne LMV, Taylor WR. Rathnayake DS, et al. Among authors: tillekeratne lmv. Cell Biochem Funct. 2024 Jun;42(4):e4036. doi: 10.1002/cbf.4036. Cell Biochem Funct. 2024. PMID: 38778584

3

CETZOLE Analogs as Potent Ferroptosis Inducers and Their Target Identification Using Covalent/Affinity Probes.

Dlamini S, Mohajeri S, Kuganesan N, Sindi SH, Karaj E, Rathnayake DS, McDaniel J, Taylor WR, Tillekeratne LMV. Dlamini S, et al. Among authors: tillekeratne lmv. J Med Chem. 2024 Sep 26;67(18):16107-16127. doi: 10.1021/acs.jmedchem.3c02084. Epub 2024 Sep 12. J Med Chem. 2024. PMID: 39264826

4

Cofilin Inhibitor Improves Neurological and Cognitive Functions after Intracerebral Hemorrhage by Suppressing Endoplasmic Reticulum Stress Related-Neuroinflammation.

Almarghalani DA, Bahader GA, Ali M, Tillekeratne LMV, Shah ZA. Almarghalani DA, et al. Among authors: tillekeratne lmv. Pharmaceuticals (Basel). 2024 Jan 15;17(1):114. doi: 10.3390/ph17010114. Pharmaceuticals (Basel). 2024. PMID: 38256947 Free PMC article.

5

First-in-Class Dual Mechanism Ferroptosis-HDAC Inhibitor Hybrids.

Karaj E, Sindi SH, Kuganesan N, Koranne RA, Knoff JR, James AW, Fu Y, Kotsull LN, Pflum MK, Shah Z, Taylor WR, Tillekeratne LMV. Karaj E, et al. Among authors: tillekeratne lmv. J Med Chem. 2022 Nov 10;65(21):14764-14791. doi: 10.1021/acs.jmedchem.2c01276. Epub 2022 Oct 28. J Med Chem. 2022. PMID: 36306372 Free PMC article.

6

Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis.

Karaj E, Sindi SH, Kuganesan N, Perera L, Taylor W, Tillekeratne LMV. Karaj E, et al. Among authors: tillekeratne lmv. J Med Chem. 2022 Sep 8;65(17):11788-11817. doi: 10.1021/acs.jmedchem.2c00909. Epub 2022 Aug 19. J Med Chem. 2022. PMID: 35984756 Free PMC article.

7

Synthesis and Development of a Novel First-in-Class Cofilin Inhibitor for Neuroinflammation in Hemorrhagic Brain Injury.

Alaqel SI, Dlamini S, Almarghalani DA, Shettigar A, Alhadidi Q, Kodithuwakku SH, Stary C, Tillekeratne LMV, Shah ZA. Alaqel SI, et al. Among authors: tillekeratne lmv. ACS Chem Neurosci. 2022 Apr 6;13(7):1014-1029. doi: 10.1021/acschemneuro.2c00010. Epub 2022 Mar 18. ACS Chem Neurosci. 2022. PMID: 35302736 Free PMC article.

8

Tumor suppressor p53 promotes ferroptosis in oxidative stress conditions independent of modulation of ferroptosis by p21, CDKs, RB, and E2F.

Kuganesan N, Dlamini S, Tillekeratne LMV, Taylor WR. Kuganesan N, et al. Among authors: tillekeratne lmv. J Biol Chem. 2021 Dec;297(6):101365. doi: 10.1016/j.jbc.2021.101365. Epub 2021 Oct 30. J Biol Chem. 2021. PMID: 34728216 Free PMC article.

9

A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.

Al-Hamashi AA, Koranne R, Dlamini S, Alqahtani A, Karaj E, Rashid MS, Knoff JR, Dunworth M, Pflum MKH, Casero RA Jr, Perera L, Taylor WR, Tillekeratne LMV. Al-Hamashi AA, et al. Among authors: tillekeratne lmv. Bioorg Chem. 2021 Nov;116:105297. doi: 10.1016/j.bioorg.2021.105297. Epub 2021 Aug 30. Bioorg Chem. 2021. PMID: 34509798 Free PMC article.

10

The structural simplification of lysergic acid as a natural lead for synthesizing novel anti-Alzheimer agents.

Alzweiri M, S Alsegiani A, Karaj E, A Almarghalani D, Tabaza Y, A Shah Z, Tillekeratne LMV. Alzweiri M, et al. Among authors: tillekeratne lmv. Bioorg Med Chem Lett. 2021 Sep 1;47:128205. doi: 10.1016/j.bmcl.2021.128205. Epub 2021 Jun 15. Bioorg Med Chem Lett. 2021. PMID: 34139326 Free PMC article.

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