Lehner PJ - Search Results

1

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling.

Randzavola LO, Mortimer PM, Garside E, Dufficy ER, Schejtman A, Roumelioti G, Yu L, Pardo M, Spirohn K, Tolley C, Brandt C, Harcourt K, Nichols E, Nahorski M, Woods G, Williamson JC, Suresh S, Sowerby JM, Matsumoto M, Santos CXC, Kiar CS, Mukhopadhyay S, Rae WM, Dougan GJ, Grainger J, Lehner PJ, Calderwood MA, Choudhary J, Clare S, Speak A, Santilli G, Bateman A, Smith KGC, Magnani F, Thomas DC. Randzavola LO, et al. Among authors: lehner pj. Elife. 2022 Nov 24;11:e76387. doi: 10.7554/eLife.76387. Elife. 2022. PMID: 36421765 Free PMC article.

2

Fluorescence-based phenotypic selection allows forward genetic screens in haploid human cells.

Duncan LM, Timms RT, Zavodszky E, Cano F, Dougan G, Randow F, Lehner PJ. Duncan LM, et al. Among authors: lehner pj. PLoS One. 2012;7(6):e39651. doi: 10.1371/journal.pone.0039651. Epub 2012 Jun 22. PLoS One. 2012. PMID: 22745803 Free PMC article.

3

Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.

Timms RT, Duncan LM, Tchasovnikarova IA, Antrobus R, Smith DL, Dougan G, Weekes MP, Lehner PJ. Timms RT, et al. Among authors: lehner pj. PLoS Pathog. 2013;9(11):e1003772. doi: 10.1371/journal.ppat.1003772. Epub 2013 Nov 21. PLoS Pathog. 2013. PMID: 24278019 Free PMC article.

4

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.

van den Boomen DJ, Timms RT, Grice GL, Stagg HR, Skødt K, Dougan G, Nathan JA, Lehner PJ. van den Boomen DJ, et al. Among authors: lehner pj. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30. doi: 10.1073/pnas.1409099111. Epub 2014 Jul 16. Proc Natl Acad Sci U S A. 2014. PMID: 25030448 Free PMC article.

5

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.

Timms RT, Menzies SA, Tchasovnikarova IA, Christensen LC, Williamson JC, Antrobus R, Dougan G, Ellgaard L, Lehner PJ. Timms RT, et al. Among authors: lehner pj. Nat Commun. 2016 Jun 10;7:11786. doi: 10.1038/ncomms11786. Nat Commun. 2016. PMID: 27283361 Free PMC article.

6

Temporal proteomic analysis of HIV infection reveals remodelling of the host phosphoproteome by lentiviral Vif variants.

Greenwood EJ, Matheson NJ, Wals K, van den Boomen DJ, Antrobus R, Williamson JC, Lehner PJ. Greenwood EJ, et al. Among authors: lehner pj. Elife. 2016 Sep 30;5:e18296. doi: 10.7554/eLife.18296. Elife. 2016. PMID: 27690223 Free PMC article.

7

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.

Timms RT, Tchasovnikarova IA, Antrobus R, Dougan G, Lehner PJ. Timms RT, et al. Among authors: lehner pj. Cell Rep. 2016 Oct 11;17(3):653-659. doi: 10.1016/j.celrep.2016.09.050. Cell Rep. 2016. PMID: 27732843 Free PMC article.

8

Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation.

Fielding CA, Weekes MP, Nobre LV, Ruckova E, Wilkie GS, Paulo JA, Chang C, Suárez NM, Davies JA, Antrobus R, Stanton RJ, Aicheler RJ, Nichols H, Vojtesek B, Trowsdale J, Davison AJ, Gygi SP, Tomasec P, Lehner PJ, Wilkinson GW. Fielding CA, et al. Among authors: lehner pj. Elife. 2017 Feb 10;6:e22206. doi: 10.7554/eLife.22206. Elife. 2017. PMID: 28186488 Free PMC article.

9

Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.

Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G, Kingston RE, Modis Y, Lehner PJ. Tchasovnikarova IA, et al. Among authors: lehner pj. Nat Genet. 2017 Jul;49(7):1035-1044. doi: 10.1038/ng.3878. Epub 2017 Jun 5. Nat Genet. 2017. PMID: 28581500 Free PMC article.

10

The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1.

Menzies SA, Volkmar N, van den Boomen DJ, Timms RT, Dickson AS, Nathan JA, Lehner PJ. Menzies SA, et al. Among authors: lehner pj. Elife. 2018 Dec 13;7:e40009. doi: 10.7554/eLife.40009. Elife. 2018. PMID: 30543180 Free PMC article.

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