Hofman J - Search Results

1

Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study.

Sabet Z, Vagiannis D, Budagaga Y, Zhang Y, Novotná E, Hanke I, Rozkoš T, Hofman J. Sabet Z, et al. Among authors: hofman j. Int J Mol Sci. 2022 Nov 18;23(22):14338. doi: 10.3390/ijms232214338. Int J Mol Sci. 2022. PMID: 36430819 Free PMC article.

2

Olomoucine II and purvalanol A inhibit ABCG2 transporter in vitro and in situ and synergistically potentiate cytostatic effect of mitoxantrone.

Hofman J, Ahmadimoghaddam D, Hahnova L, Pavek P, Ceckova M, Staud F. Hofman J, et al. Pharmacol Res. 2012 Mar;65(3):312-9. doi: 10.1016/j.phrs.2011.11.017. Epub 2011 Dec 6. Pharmacol Res. 2012. PMID: 22173067

3

Olomoucine II, but not purvalanol A, is transported by breast cancer resistance protein (ABCG2) and P-glycoprotein (ABCB1).

Hofman J, Kučera R, Cihalova D, Klimes J, Ceckova M, Staud F. Hofman J, et al. PLoS One. 2013 Oct 8;8(10):e75520. doi: 10.1371/journal.pone.0075520. eCollection 2013. PLoS One. 2013. PMID: 24116053 Free PMC article.

4

Purvalanol A, olomoucine II and roscovitine inhibit ABCB1 transporter and synergistically potentiate cytotoxic effects of daunorubicin in vitro.

Cihalova D, Hofman J, Ceckova M, Staud F. Cihalova D, et al. Among authors: hofman j. PLoS One. 2013 Dec 23;8(12):e83467. doi: 10.1371/journal.pone.0083467. eCollection 2013. PLoS One. 2013. PMID: 24376706 Free PMC article.

5

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

Hofman J, Malcekova B, Skarka A, Novotna E, Wsol V. Hofman J, et al. Toxicol Appl Pharmacol. 2014 Aug 1;278(3):238-48. doi: 10.1016/j.taap.2014.04.027. Epub 2014 May 14. Toxicol Appl Pharmacol. 2014. PMID: 24832494

6

Placental passage of olomoucine II, but not purvalanol A, is affected by p-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2) and multidrug resistance-associated proteins (ABCCs).

Hofman J, Kučera R, Neumanova Z, Klimes J, Ceckova M, Staud F. Hofman J, et al. Xenobiotica. 2016;46(5):416-23. doi: 10.3109/00498254.2015.1086039. Epub 2015 Sep 12. Xenobiotica. 2016. PMID: 26364927

7

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment.

Zemanova L, Hofman J, Novotna E, Musilek K, Lundova T, Havrankova J, Hostalkova A, Chlebek J, Cahlikova L, Wsol V. Zemanova L, et al. Among authors: hofman j. J Nat Prod. 2015 Nov 25;78(11):2666-74. doi: 10.1021/acs.jnatprod.5b00616. Epub 2015 Nov 3. J Nat Prod. 2015. PMID: 26529431

8

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro.

Sorf A, Hofman J, Kučera R, Staud F, Ceckova M. Sorf A, et al. Among authors: hofman j. Biochem Pharmacol. 2018 Aug;154:10-17. doi: 10.1016/j.bcp.2018.04.013. Epub 2018 Apr 16. Biochem Pharmacol. 2018. PMID: 29673999

9

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile.

Novotná E, Büküm N, Hofman J, Flaxová M, Kouklíková E, Louvarová D, Wsól V. Novotná E, et al. Among authors: hofman j. Arch Toxicol. 2018 Sep;92(9):2845-2857. doi: 10.1007/s00204-018-2258-0. Epub 2018 Jul 10. Arch Toxicol. 2018. PMID: 29992508

10

Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment.

Novotná E, Büküm N, Hofman J, Flaxová M, Kouklíková E, Louvarová D, Wsól V. Novotná E, et al. Among authors: hofman j. Biochem Pharmacol. 2018 Oct;156:22-31. doi: 10.1016/j.bcp.2018.08.001. Epub 2018 Aug 3. Biochem Pharmacol. 2018. PMID: 30077642

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