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Page 1
Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1.
Parsonage G, Cuthbertson K, Endesh N, Murciano N, Hyman AJ, Revill CH, Povstyan OV, Chuntharpursat-Bon E, Debant M, Ludlow MJ, Futers TS, Lichtenstein L, Kinsella JA, Bartoli F, Rotordam MG, Becker N, Brüggemann A, Foster R, Beech DJ. Parsonage G, et al. Among authors: becker n. Br J Pharmacol. 2023 Aug;180(16):2039-2063. doi: 10.1111/bph.15996. Epub 2023 Jan 31. Br J Pharmacol. 2023. PMID: 36457143 Free PMC article.
Novel screening techniques for ion channel targeting drugs.
Obergrussberger A, Stölzle-Feix S, Becker N, Brüggemann A, Fertig N, Möller C. Obergrussberger A, et al. Among authors: becker n. Channels (Austin). 2015;9(6):367-75. doi: 10.1080/19336950.2015.1079675. Epub 2015 Nov 10. Channels (Austin). 2015. PMID: 26556400 Free PMC article. Review.
An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery.
Obergrussberger A, Goetze TA, Brinkwirth N, Becker N, Friis S, Rapedius M, Haarmann C, Rinke-Weiß I, Stölzle-Feix S, Brüggemann A, George M, Fertig N. Obergrussberger A, et al. Among authors: becker n. Expert Opin Drug Discov. 2018 Mar;13(3):269-277. doi: 10.1080/17460441.2018.1428555. Epub 2018 Jan 17. Expert Opin Drug Discov. 2018. PMID: 29343120 Review.
A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm.
Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: becker n. Toxicol Appl Pharmacol. 2020 May 1;394:114961. doi: 10.1016/j.taap.2020.114961. Epub 2020 Mar 21. Toxicol Appl Pharmacol. 2020. PMID: 32209365 Free PMC article.
Corrigendum to "A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm" [Toxicology and Applied Pharmacology volume 394C (2020) 114961].
Ridder BJ, Leishman DJ, Bridgland-Taylor M, Samieegohar M, Han X, Wu WW, Randolph A, Tran P, Sheng J, Danker T, Lindqvist A, Konrad D, Hebeisen S, Polonchuk L, Gissinger E, Renganathan M, Koci B, Wei H, Fan J, Levesque P, Kwagh J, Imredy J, Zhai J, Rogers M, Humphries E, Kirby R, Stoelzle-Feix S, Brinkwirth N, Rotordam MG, Becker N, Friis S, Rapedius M, Goetze TA, Strassmaier T, Okeyo G, Kramer J, Kuryshev Y, Wu C, Himmel H, Mirams GR, Strauss DG, Bardenet R, Li Z. Ridder BJ, et al. Among authors: becker n. Toxicol Appl Pharmacol. 2020 May 15;395:114983. doi: 10.1016/j.taap.2020.114983. Epub 2020 Apr 2. Toxicol Appl Pharmacol. 2020. PMID: 32247767 Free PMC article. No abstract available.
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment.
Rotordam MG, Obergrussberger A, Brinkwirth N, Takasuna K, Becker N, Horváth A, Goetze TA, Rapedius M, Furukawa H, Hasegawa Y, Oka T, Fertig N, Stoelzle-Feix S. Rotordam MG, et al. Among authors: becker n. J Pharmacol Toxicol Methods. 2021 Nov-Dec;112:107125. doi: 10.1016/j.vascn.2021.107125. Epub 2021 Sep 6. J Pharmacol Toxicol Methods. 2021. PMID: 34500078
The suitability of high throughput automated patch clamp for physiological applications.
Obergrussberger A, Rinke-Weiß I, Goetze TA, Rapedius M, Brinkwirth N, Becker N, Rotordam MG, Hutchison L, Madau P, Pau D, Dalrymple D, Braun N, Friis S, Pless SA, Fertig N. Obergrussberger A, et al. Among authors: becker n. J Physiol. 2022 Jan;600(2):277-297. doi: 10.1113/JP282107. Epub 2021 Oct 8. J Physiol. 2022. PMID: 34555195 Free article.
Transient receptor potential channel vanilloid type 2 in red cells of cannabis consumer.
Flormann D, Qiao M, Murciano N, Iacono G, Darras A, Hof S, Recktenwald SM, Rotordam MG, Becker N, Geisel J, Wagner C, von Lindern M, van den Akker E, Kaestner L. Flormann D, et al. Among authors: becker n. Am J Hematol. 2022 May;97(5):E180-E183. doi: 10.1002/ajh.26509. Epub 2022 Feb 25. Am J Hematol. 2022. PMID: 35179248 Free article. No abstract available.
1,079 results