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All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex.
Wang L, Zhang Q, Ye L, Ye X, Yang W, Zhang H, Zhou X, Ren Y, Ma L, Zhang X, Mei C, Xu G, Li K, Luo Y, Jiang L, Lin P, Zhu S, Lang W, Wang Y, Shen C, Han Y, Liu X, Yang H, Lu C, Sun J, Jin J, Tong H. Wang L, et al. Among authors: zhou x. Br J Cancer. 2023 Feb;128(4):691-701. doi: 10.1038/s41416-022-02074-0. Epub 2022 Dec 8. Br J Cancer. 2023. PMID: 36482192 Free PMC article.
Epigenetic priming with decitabine followed by low-dose idarubicin/cytarabine has an increased anti-leukemic effect compared to traditional chemotherapy in high-risk myeloid neoplasms.
Ye XN, Zhou XP, Wei JY, Xu GX, Li Y, Mao LP, Huang J, Ren YL, Mei C, Wang JH, Lou YJ, Ma LY, Yu WJ, Ye L, Xie LL, Luo YW, Hu C, Niu LM, Dou MH, Jin J, Tong HY. Ye XN, et al. Leuk Lymphoma. 2016;57(6):1311-8. doi: 10.3109/10428194.2015.1091931. Epub 2015 Oct 13. Leuk Lymphoma. 2016. PMID: 26372888
Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone.
Ye L, Ren Y, Zhou X, Mei C, Ma L, Ye X, Wei J, Xu W, Meng H, Qian W, Mai W, Lou Y, Xu G, Qian J, Lou Y, Luo Y, Xie L, Lin P, Hu C, Jin J, Tong H. Ye L, et al. Among authors: zhou x. J Cancer Res Clin Oncol. 2017 May;143(5):873-882. doi: 10.1007/s00432-016-2331-0. Epub 2017 Jan 20. J Cancer Res Clin Oncol. 2017. PMID: 28108816 Free PMC article.
Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes.
Lin P, Luo Y, Zhu S, Maggio D, Yang H, Hu C, Wang J, Zhang H, Ren Y, Zhou X, Mei C, Ma L, Xu W, Ye L, Zhuang Z, Jin J, Tong H. Lin P, et al. Among authors: zhou x. J Cancer Res Clin Oncol. 2018 Jun;144(6):1037-1047. doi: 10.1007/s00432-018-2627-3. Epub 2018 Mar 16. J Cancer Res Clin Oncol. 2018. PMID: 29549529
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