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The CD3 zeta subunit contains a phosphoinositide-binding motif that is required for the stable accumulation of TCR-CD3 complex at the immunological synapse.
DeFord-Watts LM, Dougall DS, Belkaya S, Johnson BA, Eitson JL, Roybal KT, Barylko B, Albanesi JP, Wülfing C, van Oers NS. DeFord-Watts LM, et al. Among authors: roybal kt. J Immunol. 2011 Jun 15;186(12):6839-47. doi: 10.4049/jimmunol.1002721. Epub 2011 May 4. J Immunol. 2011. PMID: 21543646 Free PMC article.
Spatiotemporal patterning during T cell activation is highly diverse.
Singleton KL, Roybal KT, Sun Y, Fu G, Gascoigne NR, van Oers NS, Wülfing C. Singleton KL, et al. Among authors: roybal kt. Sci Signal. 2009 Apr 7;2(65):ra15. doi: 10.1126/scisignal.2000199. Sci Signal. 2009. PMID: 19351954 Free PMC article.
Mania-like behavior induced by disruption of CLOCK.
Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA Jr, McClung CA. Roybal K, et al. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6406-11. doi: 10.1073/pnas.0609625104. Epub 2007 Mar 22. Proc Natl Acad Sci U S A. 2007. PMID: 17379666 Free PMC article.
49 results