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Human genetic diversity alters off-target outcomes of therapeutic gene editing.
Cancellieri S, Zeng J, Lin LY, Tognon M, Nguyen MA, Lin J, Bombieri N, Maitland SA, Ciuculescu MF, Katta V, Tsai SQ, Armant M, Wolfe SA, Giugno R, Bauer DE, Pinello L. Cancellieri S, et al. Among authors: lin j, lin ly. Nat Genet. 2023 Jan;55(1):34-43. doi: 10.1038/s41588-022-01257-y. Epub 2022 Dec 15. Nat Genet. 2023. PMID: 36522432 Free PMC article.
Precise DNA cleavage using CRISPR-SpRYgests.
Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP. Christie KA, et al. Among authors: lin j. Nat Biotechnol. 2023 Mar;41(3):409-416. doi: 10.1038/s41587-022-01492-y. Epub 2022 Oct 6. Nat Biotechnol. 2023. PMID: 36203014 Free PMC article.
Scalable assessment of genome editing off-targets associated with genetic variants.
Lin J, Nguyen MA, Lin LY, Zeng J, Verma A, Neri NR, da Silva LF, Mucci A, Wolfe S, Shaw KL, Clement K, Brendel C, Pinello L, Pellin D, Bauer DE. Lin J, et al. Among authors: lin ly. bioRxiv [Preprint]. 2024 Jul 25:2024.07.24.605019. doi: 10.1101/2024.07.24.605019. bioRxiv. 2024. PMID: 39211178 Free PMC article. Preprint.
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