Watanabe M - Search Results

1

Delivering mRNA to Secondary Lymphoid Tissues by Phosphatidylserine-Loaded Lipid Nanoparticles.

Gomi M, Sakurai Y, Sato M, Tanaka H, Miyatake Y, Fujiwara K, Watanabe M, Shuto S, Nakai Y, Tange K, Hatakeyama H, Akita H. Gomi M, et al. Among authors: watanabe m. Adv Healthc Mater. 2023 Apr;12(9):e2202528. doi: 10.1002/adhm.202202528. Epub 2022 Dec 25. Adv Healthc Mater. 2023. PMID: 36535635

2

Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure.

Watanabe M, Kazuta Y, Hayashi H, Yamada S, Matsuda A, Shuto S. Watanabe M, et al. J Med Chem. 2006 Sep 7;49(18):5587-96. doi: 10.1021/jm0603318. J Med Chem. 2006. PMID: 16942032

3

Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands.

Kobayashi T, Watanabe M, Yoshida A, Yamada S, Ito M, Abe H, Ito Y, Arisawa M, Shuto S. Kobayashi T, et al. Among authors: watanabe m. Bioorg Med Chem. 2010 Feb;18(3):1076-82. doi: 10.1016/j.bmc.2009.12.046. Epub 2009 Dec 23. Bioorg Med Chem. 2010. PMID: 20045649

4

Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy.

Watanabe M, Hirokawa T, Kobayashi T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S. Watanabe M, et al. J Med Chem. 2010 May 13;53(9):3585-93. doi: 10.1021/jm901848b. J Med Chem. 2010. PMID: 20397706

5

Synthesis of a series of 3,4-methanoarginines as side-chain conformationally restricted analogues of arginine.

Watanabe M, Yamaguchi K, Tang W, Yoshida K, Silverman RB, Arisawa M, Shuto S. Watanabe M, et al. Bioorg Med Chem. 2011 Oct 15;19(20):5984-8. doi: 10.1016/j.bmc.2011.08.049. Epub 2011 Aug 27. Bioorg Med Chem. 2011. PMID: 21917467

6

Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone.

Watanabe M, Kobayashi T, Hirokawa T, Yoshida A, Ito Y, Yamada S, Orimoto N, Yamasaki Y, Arisawa M, Shuto S. Watanabe M, et al. Org Biomol Chem. 2012 Jan 28;10(4):736-45. doi: 10.1039/c1ob06496g. Epub 2011 Nov 28. Org Biomol Chem. 2012. PMID: 22120611

7

Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain.

Mizuno A, Miura S, Watanabe M, Ito Y, Yamada S, Odagami T, Kogami Y, Arisawa M, Shuto S. Mizuno A, et al. Among authors: watanabe m. Org Lett. 2013 Apr 5;15(7):1686-9. doi: 10.1021/ol400469w. Epub 2013 Mar 25. Org Lett. 2013. PMID: 23528142

8

Preparation of chiral bromomethylenecyclopropane and its use in Suzuki-Miyaura coupling: synthesis of the arylmethyl-(Z)-cyclopropane structure core.

Tanabe M, Watanabe M, Hoshiya N, Mizuno A, Fukuda H, Arisawa M, Shuto S. Tanabe M, et al. Among authors: watanabe m. J Org Chem. 2013 Dec 6;78(23):11714-20. doi: 10.1021/jo401675z. Epub 2013 Nov 20. J Org Chem. 2013. PMID: 24206361

9

Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

Sato T, Watanabe M, Tsuzuki T, Takano S, Murayama T, Sakurai T, Kameda T, Fukuda H, Arisawa M, Shuto S. Sato T, et al. Among authors: watanabe m. J Med Chem. 2016 Aug 11;59(15):7282-6. doi: 10.1021/acs.jmedchem.6b00437. Epub 2016 Jul 20. J Med Chem. 2016. PMID: 27391373

10

Cyclopropane-Based Peptidomimetics Mimicking Wide-Ranging Secondary Structures of Peptides: Conformational Analysis and Their Use in Rational Ligand Optimization.

Mizuno A, Kameda T, Kuwahara T, Endoh H, Ito Y, Yamada S, Hasegawa K, Yamano A, Watanabe M, Arisawa M, Shuto S. Mizuno A, et al. Among authors: watanabe m. Chemistry. 2017 Mar 2;23(13):3159-3168. doi: 10.1002/chem.201605312. Epub 2017 Feb 1. Chemistry. 2017. PMID: 28000361

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