Aaltonen L - Search Results

1

Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.

Fernandez-Rozadilla C, Timofeeva M, Chen Z, Law P, Thomas M, Schmit S, Díez-Obrero V, Hsu L, Fernandez-Tajes J, Palles C, Sherwood K, Briggs S, Svinti V, Donnelly K, Farrington S, Blackmur J, Vaughan-Shaw P, Shu XO, Long J, Cai Q, Guo X, Lu Y, Broderick P, Studd J, Huyghe J, Harrison T, Conti D, Dampier C, Devall M, Schumacher F, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Moratalla-Navarro F, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper J, Jenkins M, Win AK, Pai R, Figueiredo J, Haile R, Gallinger S, Woods M, Newcomb P, Duggan D, Cheadle J, Kaplan R, Maughan T, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin LP, Jousilahti P, Knekt P, Aaltonen L, Rissanen H, Pukkala E, Eriksson J, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Zanke B, Männistö S, Albanes D, Weinstein S, Ruiz-Narvaez E, Palmer J, Buchanan D, Platz E, Visvanathan K, Ulrich C, Siegel E, Brezina S, Gsur A, Campbell P, Chang-Claude J, Hoffmeister M, Brenner H, Slattery M, Potter J, Tsilidis K, Schulze M, Gunter M, Murphy N, Castells A, Castellví-Bel S, Moreira L, Arndt V,… See abstract for full author list ➔ Fernandez-Rozadilla C, et al. Among authors: aaltonen l. Nat Genet. 2023 Jan;55(1):89-99. doi: 10.1038/s41588-022-01222-9. Epub 2022 Dec 20. Nat Genet. 2023. PMID: 36539618 Free PMC article.

2

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer.

Hemminki A, Peltomäki P, Mecklin JP, Järvinen H, Salovaara R, Nyström-Lahti M, de la Chapelle A, Aaltonen LA. Hemminki A, et al. Among authors: aaltonen la. Nat Genet. 1994 Dec;8(4):405-10. doi: 10.1038/ng1294-405. Nat Genet. 1994. PMID: 7894494

3

A novel approach to estimate the proportion of hereditary nonpolyposis colorectal cancer of total colorectal cancer burden.

Aaltonen LA, Sankila R, Mecklin JP, Järvinen H, Pukkala E, Peltomäki P, de la Chapelle A. Aaltonen LA, et al. Cancer Detect Prev. 1994;18(1):57-63. Cancer Detect Prev. 1994. PMID: 8162607

4

Somatic microsatellite mutations as molecular tumor clocks.

Shibata D, Navidi W, Salovaara R, Li ZH, Aaltonen LA. Shibata D, et al. Among authors: aaltonen la. Nat Med. 1996 Jun;2(6):676-81. doi: 10.1038/nm0696-676. Nat Med. 1996. PMID: 8640559

5

Telomerase activity is commonly detected in hereditary nonpolyposis colorectal cancers.

Li ZH, Salovaara R, Aaltonen LA, Shibata D. Li ZH, et al. Among authors: aaltonen la. Am J Pathol. 1996 Apr;148(4):1075-9. Am J Pathol. 1996. PMID: 8644849 Free PMC article.

6

Effects of mutation and growth rates on patterns of microsatellite instability.

Li ZH, Aaltonen LA, Shu Q, Srivastava S, Grizzle WE, Shibata D. Li ZH, et al. Among authors: aaltonen la. Am J Pathol. 1996 Jun;148(6):1757-61. Am J Pathol. 1996. PMID: 8669462 Free PMC article.

7

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.

Hemminki A, Tomlinson I, Markie D, Järvinen H, Sistonen P, Björkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la Chapelle A, Aaltonen LA. Hemminki A, et al. Among authors: aaltonen la. Nat Genet. 1997 Jan;15(1):87-90. doi: 10.1038/ng0197-87. Nat Genet. 1997. PMID: 8988175

8

Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture.

Tsao JL, Zhang J, Salovaara R, Li ZH, Järvinen HJ, Mecklin JP, Aaltonen LA, Shibata D. Tsao JL, et al. Among authors: aaltonen la. Am J Pathol. 1998 Oct;153(4):1189-200. doi: 10.1016/S0002-9440(10)65663-5. Am J Pathol. 1998. PMID: 9777950 Free PMC article.

9

Colorectal adenoma and cancer divergence. Evidence of multilineage progression.

Tsao JL, Tavaré S, Salovaara R, Jass JR, Aaltonen LA, Shibata D. Tsao JL, et al. Among authors: aaltonen la. Am J Pathol. 1999 Jun;154(6):1815-24. doi: 10.1016/S0002-9440(10)65437-5. Am J Pathol. 1999. PMID: 10362806 Free PMC article.

10

Genetic predisposition and somatic diversification in tumor development and progression.

Shibata D, Aaltonen LA. Shibata D, et al. Among authors: aaltonen la. Adv Cancer Res. 2001;80:83-114. doi: 10.1016/s0065-230x(01)80013-0. Adv Cancer Res. 2001. PMID: 11034541 Review.

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