Malik R - Search Results

1

Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications.

Shahpasand-Kroner H, Siddique I, Malik R, Linares GR, Ivanova MI, Ichida J, Weil T, Münch J, Sanchez-Garcia E, Klärner FG, Schrader T, Bitan G. Shahpasand-Kroner H, et al. Among authors: malik r. Pharmacol Rev. 2023 Mar;75(2):263-308. doi: 10.1124/pharmrev.122.000654. Epub 2022 Dec 22. Pharmacol Rev. 2023. PMID: 36549866 Free PMC article. Review.

2

Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins.

Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G. Malik R, et al. Methods Mol Biol. 2018;1777:369-386. doi: 10.1007/978-1-4939-7811-3_24. Methods Mol Biol. 2018. PMID: 29744849 Free PMC article.

3

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS.

Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G. Malik R, et al. J Biol Chem. 2019 Mar 8;294(10):3501-3513. doi: 10.1074/jbc.RA118.005940. Epub 2019 Jan 2. J Biol Chem. 2019. PMID: 30602569 Free PMC article.

4

Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency.

Mason AJ, Hurst I, Malik R, Siddique I, Solomonov I, Sagi I, Klärner FG, Schrader T, Bitan G. Mason AJ, et al. Among authors: malik r. ACS Chem Neurosci. 2020 Aug 5;11(15):2243-2255. doi: 10.1021/acschemneuro.0c00192. Epub 2020 Jul 7. ACS Chem Neurosci. 2020. PMID: 32559370 Free PMC article.

5

Examination of SOD1 aggregation modulators and their effect on SOD1 enzymatic activity as a proxy for potential toxicity.

Malik R, Corrales C, Linsenmeier M, Alalami H, Sepanj N, Bitan G. Malik R, et al. FASEB J. 2020 Sep;34(9):11957-11969. doi: 10.1096/fj.202000948R. Epub 2020 Jul 23. FASEB J. 2020. PMID: 32701214 Free PMC article.

6

Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light.

Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A. Daloglu MU, et al. Among authors: malik r. Sci Rep. 2017 Mar 9;7:44157. doi: 10.1038/srep44157. Sci Rep. 2017. PMID: 28276489 Free PMC article.

7

Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.

Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G. Atlasi RS, et al. Among authors: malik r. ACS Chem Biol. 2018 Sep 21;13(9):2794-2807. doi: 10.1021/acschembio.8b00729. Epub 2018 Aug 30. ACS Chem Biol. 2018. PMID: 30110532 Free PMC article.

8

Therapeutic Approaches Targeting Protein Aggregation in Amyotrophic Lateral Sclerosis.

Malik R, Wiedau M. Malik R, et al. Front Mol Neurosci. 2020 Jun 9;13:98. doi: 10.3389/fnmol.2020.00098. eCollection 2020. Front Mol Neurosci. 2020. PMID: 32581709 Free PMC article. Review.

9

Ethnopharmacological Perspective for Treatment of Epilepsy: An Updated Review.

Kalra S, Bhatia S, Harrasi AA, Mohan S, Sachdeva H, Sharma D, Budhwar V, Choudhary M, Malik R. Kalra S, et al. Among authors: malik r. Scientifica (Cairo). 2024 Nov 20;2024:8052659. doi: 10.1155/2024/8052659. eCollection 2024. Scientifica (Cairo). 2024. PMID: 39610870 Free PMC article. Review.

10

A DAT1 gene and APOE ε4 interaction is associated with apathy and structural brain changes in mild cognitive impairment and Alzheimer's disease.

Malik R, Beaton D, Ahmed J, Nho K, Saykin AJ, Wang J, Hegele RA, Finger E; Alzheimer's Disease Neuroimaging Initiative. Malik R, et al. J Alzheimers Dis. 2024 Nov 29:13872877241299785. doi: 10.1177/13872877241299785. Online ahead of print. J Alzheimers Dis. 2024. PMID: 39610284

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