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Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Polymenidou M, Lagier-Tourenne C, Hutt KR, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW. Polymenidou M, et al. Among authors: yeo gw. Nat Neurosci. 2011 Apr;14(4):459-68. doi: 10.1038/nn.2779. Epub 2011 Feb 27. Nat Neurosci. 2011. PMID: 21358643 Free PMC article.
Misregulated RNA processing in amyotrophic lateral sclerosis.
Polymenidou M, Lagier-Tourenne C, Hutt KR, Bennett CF, Cleveland DW, Yeo GW. Polymenidou M, et al. Among authors: yeo gw. Brain Res. 2012 Jun 26;1462:3-15. doi: 10.1016/j.brainres.2012.02.059. Epub 2012 Mar 3. Brain Res. 2012. PMID: 22444279 Free PMC article. Review.
LIN28 binds messenger RNAs at GGAGA motifs and regulates splicing factor abundance.
Wilbert ML, Huelga SC, Kapeli K, Stark TJ, Liang TY, Chen SX, Yan BY, Nathanson JL, Hutt KR, Lovci MT, Kazan H, Vu AQ, Massirer KB, Morris Q, Hoon S, Yeo GW. Wilbert ML, et al. Among authors: yeo gw. Mol Cell. 2012 Oct 26;48(2):195-206. doi: 10.1016/j.molcel.2012.08.004. Epub 2012 Sep 6. Mol Cell. 2012. PMID: 22959275 Free PMC article.
Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs.
Lagier-Tourenne C, Polymenidou M, Hutt KR, Vu AQ, Baughn M, Huelga SC, Clutario KM, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW, Yeo GW. Lagier-Tourenne C, et al. Among authors: yeo gw. Nat Neurosci. 2012 Nov;15(11):1488-97. doi: 10.1038/nn.3230. Epub 2012 Sep 30. Nat Neurosci. 2012. PMID: 23023293 Free PMC article.
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration.
Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. Lagier-Tourenne C, et al. Among authors: yeo gw. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4530-9. doi: 10.1073/pnas.1318835110. Epub 2013 Oct 29. Proc Natl Acad Sci U S A. 2013. PMID: 24170860 Free PMC article.
Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses.
Kapeli K, Pratt GA, Vu AQ, Hutt KR, Martinez FJ, Sundararaman B, Batra R, Freese P, Lambert NJ, Huelga SC, Chun SJ, Liang TY, Chang J, Donohue JP, Shiue L, Zhang J, Zhu H, Cambi F, Kasarskis E, Hoon S, Ares M Jr, Burge CB, Ravits J, Rigo F, Yeo GW. Kapeli K, et al. Among authors: yeo gw. Nat Commun. 2016 Jul 5;7:12143. doi: 10.1038/ncomms12143. Nat Commun. 2016. PMID: 27378374 Free PMC article.
280 results