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316 results

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Page 1
Identification of HMGA2 as a predictive biomarker of response to bintrafusp alfa in a phase 1 trial in patients with advanced triple-negative breast cancer.
Spira A, Awada A, Isambert N, Lorente D, Penel N, Zhang Y, Ojalvo LS, Hicking C, Rolfe PA, Ihling C, Dussault I, Locke G, Borel C. Spira A, et al. Among authors: locke g. Front Oncol. 2022 Dec 8;12:981940. doi: 10.3389/fonc.2022.981940. eCollection 2022. Front Oncol. 2022. PMID: 36568239 Free PMC article.
Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients With Non-Small Cell Lung Cancer Resistant or Refractory to Immune Checkpoint Inhibitors.
Barlesi F, Isambert N, Felip E, Cho BC, Lee DH, Peguero J, Jerusalem G, Penel N, Saada-Bouzid E, Garrido P, Helwig C, Locke G, Ojalvo LS, Gulley JL. Barlesi F, et al. Among authors: locke g. Oncologist. 2023 Mar 17;28(3):258-267. doi: 10.1093/oncolo/oyac253. Oncologist. 2023. PMID: 36571770 Free PMC article.
Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses.
Lan Y, Yeung TL, Huang H, Wegener AA, Saha S, Toister-Achituv M, Jenkins MH, Chiu LY, Lazorchak A, Tarcic O, Wang H, Qi J, Locke G, Kalimi D, Qin G, Marelli B, Yu H, Gross AW, Derner MG, Soloviev M, Botte M, Sircar A, Ma H, Sood VD, Zhang D, Jiang F, Lo KM. Lan Y, et al. Among authors: locke g. J Immunother Cancer. 2022 Jul;10(7):e004122. doi: 10.1136/jitc-2021-004122. J Immunother Cancer. 2022. PMID: 35858707 Free PMC article.
Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion.
Lan Y, Moustafa M, Knoll M, Xu C, Furkel J, Lazorchak A, Yeung TL, Hasheminasab SM, Jenkins MH, Meister S, Yu H, Schlegel J, Marelli B, Tang Z, Qin G, Klein C, Qi J, Zhou C, Locke G, Krunic D, Derner MG, Schwager C, Fontana RE, Kriegsmann K, Jiang F, Rein K, Kriegsmann M, Debus J, Lo KM, Abdollahi A. Lan Y, et al. Among authors: locke g. Cancer Cell. 2021 Oct 11;39(10):1388-1403.e10. doi: 10.1016/j.ccell.2021.08.008. Epub 2021 Sep 9. Cancer Cell. 2021. PMID: 34506739 Free article.
Discovery and Synthesis of Heterobifunctional Degraders of Rearranged during Transfection (RET) Kinase.
Qiao JX, Williams D, Gill P, Li L, Norris D, Tokarski JS, Wong J, Qi H, Hafeji Y, Downes DP, Degnen B, Wang YK, Locke G, Fang H, Yu F, Xu S, Naglich J, Zhang J, Nanjappa P, Dai C, Chourb L, Napoline J, Tester R, Jorge C, Li YX, Mathur A, Barbieri C, Soars MG, Venkatanarayan A, Lees E, Borzilleri RM, Gavai AV, Wichroski M, Dhar TGM. Qiao JX, et al. Among authors: locke g. J Med Chem. 2024 Nov 14;67(21):19736-19754. doi: 10.1021/acs.jmedchem.4c02083. Epub 2024 Oct 22. J Med Chem. 2024. PMID: 39437163
Next-generation Drosophila protein interactome map and its functional implications.
Bhat G, Li K, Locke G, Theodorou M, Kilambi K, Hori K, Ho D, Obar R, Williams L, Parzen H, Dephoure N, Braun C, Muskavitch M, Celniker SE, Gygi S, Artavanis-Tsakonas S. Bhat G, et al. Among authors: locke g. Dev Cell. 2024 Sep 23;59(18):2506-2517.e6. doi: 10.1016/j.devcel.2024.06.002. Epub 2024 Jun 28. Dev Cell. 2024. PMID: 38944040
Cancer Center Staff Satisfaction: Descriptive Results of a Canadian Study.
Samant R, Babadagli E, Laprade S, Locke GE, Zhang Y, McNeil A, Renaud J, Cisa-Paré E, Chan J, Song J, Meng J. Samant R, et al. Among authors: locke ge. Curr Oncol. 2023 Nov 11;30(11):9872-9885. doi: 10.3390/curroncol30110717. Curr Oncol. 2023. PMID: 37999137 Free PMC article.
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.
Wichroski M, Benci J, Liu SQ, Chupak L, Fang J, Cao C, Wang C, Onorato J, Qiu H, Shan Y, Banas D, Powles R, Locke G, Witt A, Stromko C, Qi H, Zheng X, Martin S, Ding M, Gentles R, Meanwell N, Velaparthi U, Olson R, Wee S, Tenney D, Parker CG, Cravatt BF, Lawrence M, Borzilleri R, Lees E. Wichroski M, et al. Among authors: locke g. Sci Transl Med. 2023 Oct 25;15(719):eadh1892. doi: 10.1126/scitranslmed.adh1892. Epub 2023 Oct 25. Sci Transl Med. 2023. PMID: 37878674
316 results