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Page 1
Targeted degradation via direct 26S proteasome recruitment.
Bashore C, Prakash S, Johnson MC, Conrad RJ, Kekessie IA, Scales SJ, Ishisoko N, Kleinheinz T, Liu PS, Popovych N, Wecksler AT, Zhou L, Tam C, Zilberleyb I, Srinivasan R, Blake RA, Song A, Staben ST, Zhang Y, Arnott D, Fairbrother WJ, Foster SA, Wertz IE, Ciferri C, Dueber EC. Bashore C, et al. Among authors: fairbrother wj. Nat Chem Biol. 2023 Jan;19(1):55-63. doi: 10.1038/s41589-022-01218-w. Epub 2022 Dec 28. Nat Chem Biol. 2023. PMID: 36577875 Free PMC article.
c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.
Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D. Dynek JN, et al. Among authors: fairbrother wj. EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26. EMBO J. 2010. PMID: 21113135 Free PMC article.
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.
Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM. Wertz IE, et al. Among authors: fairbrother wj. Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Nature. 2011. PMID: 21368834
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Dueber EC, Schoeffler AJ, Lingel A, Elliott JM, Fedorova AV, Giannetti AM, Zobel K, Maurer B, Varfolomeev E, Wu P, Wallweber HJ, Hymowitz SG, Deshayes K, Vucic D, Fairbrother WJ. Dueber EC, et al. Among authors: fairbrother wj. Science. 2011 Oct 21;334(6054):376-80. doi: 10.1126/science.1207862. Science. 2011. PMID: 22021857
Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.
Phillips AH, Zhang Y, Cunningham CN, Zhou L, Forrest WF, Liu PS, Steffek M, Lee J, Tam C, Helgason E, Murray JM, Kirkpatrick DS, Fairbrother WJ, Corn JE. Phillips AH, et al. Among authors: fairbrother wj. Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11379-84. doi: 10.1073/pnas.1302407110. Epub 2013 Jun 25. Proc Natl Acad Sci U S A. 2013. PMID: 23801757 Free PMC article.
Internal motions prime cIAP1 for rapid activation.
Phillips AH, Schoeffler AJ, Matsui T, Weiss TM, Blankenship JW, Zobel K, Giannetti AM, Dueber EC, Fairbrother WJ. Phillips AH, et al. Among authors: fairbrother wj. Nat Struct Mol Biol. 2014 Dec;21(12):1068-74. doi: 10.1038/nsmb.2916. Epub 2014 Nov 10. Nat Struct Mol Biol. 2014. PMID: 25383668
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM. Wertz IE, et al. Among authors: fairbrother wj. Nature. 2015 Dec 17;528(7582):370-5. doi: 10.1038/nature16165. Epub 2015 Dec 9. Nature. 2015. PMID: 26649818
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation.
Wertz IE, Newton K, Seshasayee D, Kusam S, Lam C, Zhang J, Popovych N, Helgason E, Schoeffler A, Jeet S, Ramamoorthi N, Kategaya L, Newman RJ, Horikawa K, Dugger D, Sandoval W, Mukund S, Zindal A, Martin F, Quan C, Tom J, Fairbrother WJ, Townsend M, Warming S, DeVoss J, Liu J, Dueber E, Caplazi P, Lee WP, Goodnow CC, Balazs M, Yu K, Kolumam G, Dixit VM. Wertz IE, et al. Among authors: fairbrother wj. Nature. 2016 Apr 21;532(7599):402. doi: 10.1038/nature16541. Epub 2016 Jan 13. Nature. 2016. PMID: 26760210 No abstract available.
126 results