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Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability.
Wu H, Murray J, Ishisoko N, Frommlet A, Deshmukh G, DiPasquale A, Mulvihill MM, Zhang D, Quinn JG, Blake RA, Fairbrother WJ, Fuhrmann J. Wu H, et al. Among authors: ishisoko n. J Med Chem. 2024 Jun 13;67(11):8585-8608. doi: 10.1021/acs.jmedchem.3c02203. Epub 2024 May 29. J Med Chem. 2024. PMID: 38809766
Targeted degradation via direct 26S proteasome recruitment.
Bashore C, Prakash S, Johnson MC, Conrad RJ, Kekessie IA, Scales SJ, Ishisoko N, Kleinheinz T, Liu PS, Popovych N, Wecksler AT, Zhou L, Tam C, Zilberleyb I, Srinivasan R, Blake RA, Song A, Staben ST, Zhang Y, Arnott D, Fairbrother WJ, Foster SA, Wertz IE, Ciferri C, Dueber EC. Bashore C, et al. Among authors: ishisoko n. Nat Chem Biol. 2023 Jan;19(1):55-63. doi: 10.1038/s41589-022-01218-w. Epub 2022 Dec 28. Nat Chem Biol. 2023. PMID: 36577875 Free PMC article.
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, Ishisoko N, Kildebeck E, Newman AM, Bratman SV, Porteus MH, Chang HY, Alizadeh AA, Diehn M. Esfahani MS, et al. Among authors: ishisoko n. Nat Commun. 2019 Dec 13;10(1):5712. doi: 10.1038/s41467-019-13392-y. Nat Commun. 2019. PMID: 31836708 Free PMC article.