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CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation.
Jordan-Paiz A, Martrus G, Steinert FL, Kaufmann M, Sagebiel AF, Schreurs RRCE, Rechtien A, Baumdick ME, Jung JM, Möller KJ, Wegner L, Grüttner C, Richert L, Thünauer R, Schroeder-Schwarz J, van Goudoever JB, Geijtenbeek TBH, Altfeld M, Pals ST, Perez D, Klarenbeek PL, Tomuschat C, Sauter G, Königs I, Schumacher U, Friese MA, Melling N, Reinshagen K, Bunders MJ. Jordan-Paiz A, et al. Among authors: klarenbeek pl. Cell Mol Immunol. 2023 Feb;20(2):201-213. doi: 10.1038/s41423-022-00944-4. Epub 2023 Jan 5. Cell Mol Immunol. 2023. PMID: 36600048 Free PMC article.
Human Fetal TNF-α-Cytokine-Producing CD4+ Effector Memory T Cells Promote Intestinal Development and Mediate Inflammation Early in Life.
Schreurs RRCE, Baumdick ME, Sagebiel AF, Kaufmann M, Mokry M, Klarenbeek PL, Schaltenberg N, Steinert FL, van Rijn JM, Drewniak A, The SML, Bakx R, Derikx JPM, de Vries N, Corpeleijn WE, Pals ST, Gagliani N, Friese MA, Middendorp S, Nieuwenhuis EES, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Schreurs RRCE, et al. Among authors: klarenbeek pl. Immunity. 2019 Feb 19;50(2):462-476.e8. doi: 10.1016/j.immuni.2018.12.010. Epub 2019 Feb 12. Immunity. 2019. PMID: 30770246 Free article.
Intestinal CD8+ T cell responses are abundantly induced early in human development but show impaired cytotoxic effector capacities.
Schreurs RRCE, Sagebiel AF, Steinert FL, Highton AJ, Klarenbeek PL, Drewniak A, Bakx R, The SML, Ribeiro CMS, Perez D, Reinshagen K, Geijtenbeek TBH, van Goudoever JB, Bunders MJ. Schreurs RRCE, et al. Among authors: klarenbeek pl. Mucosal Immunol. 2021 May;14(3):605-614. doi: 10.1038/s41385-021-00382-x. Epub 2021 Mar 26. Mucosal Immunol. 2021. PMID: 33772147 Free PMC article.
Human T-cell memory consists mainly of unexpanded clones.
Klarenbeek PL, Tak PP, van Schaik BD, Zwinderman AH, Jakobs ME, Zhang Z, van Kampen AH, van Lier RA, Baas F, de Vries N. Klarenbeek PL, et al. Immunol Lett. 2010 Sep 6;133(1):42-8. doi: 10.1016/j.imlet.2010.06.011. Epub 2010 Jul 16. Immunol Lett. 2010. PMID: 20621124
Deep sequencing of antiviral T-cell responses to HCMV and EBV in humans reveals a stable repertoire that is maintained for many years.
Klarenbeek PL, Remmerswaal EB, ten Berge IJ, Doorenspleet ME, van Schaik BD, Esveldt RE, Koch SD, ten Brinke A, van Kampen AH, Bemelman FJ, Tak PP, Baas F, de Vries N, van Lier RA. Klarenbeek PL, et al. PLoS Pathog. 2012 Sep;8(9):e1002889. doi: 10.1371/journal.ppat.1002889. Epub 2012 Sep 27. PLoS Pathog. 2012. PMID: 23028307 Free PMC article.
38 results