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Pharmacotypes across the genomic landscape of pediatric acute lymphoblastic leukemia and impact on treatment response.
Lee SHR, Yang W, Gocho Y, John A, Rowland L, Smart B, Williams H, Maxwell D, Hunt J, Yang W, Crews KR, Roberts KG, Jeha S, Cheng C, Karol SE, Relling MV, Rosner GL, Inaba H, Mullighan CG, Pui CH, Evans WE, Yang JJ. Lee SHR, et al. Among authors: smart b. Nat Med. 2023 Jan;29(1):170-179. doi: 10.1038/s41591-022-02112-7. Epub 2023 Jan 5. Nat Med. 2023. PMID: 36604538 Free PMC article.
Pharmacogenomics of intracellular methotrexate polyglutamates in patients' leukemia cells in vivo.
Lopez-Lopez E, Autry RJ, Smith C, Yang W, Paugh SW, Panetta JC, Crews KR, Bonten EJ, Smart B, Pei D, McCorkle JR, Diouf B, Roberts KG, Shi L, Pounds S, Cheng C, Mullighan CG, Pui CH, Relling MV, Evans WE. Lopez-Lopez E, et al. Among authors: smart b. J Clin Invest. 2020 Dec 1;130(12):6600-6615. doi: 10.1172/JCI140797. J Clin Invest. 2020. PMID: 33164984 Free PMC article.
Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia.
Gocho Y, Liu J, Hu J, Yang W, Dharia NV, Zhang J, Shi H, Du G, John A, Lin TN, Hunt J, Huang X, Ju B, Rowland L, Shi L, Maxwell D, Smart B, Crews KR, Yang W, Hagiwara K, Zhang Y, Roberts K, Wang H, Jabbour E, Stock W, Eisfelder B, Paietta E, Newman S, Roti G, Litzow M, Easton J, Zhang J, Peng J, Chi H, Pounds S, Relling MV, Inaba H, Zhu X, Kornblau S, Pui CH, Konopleva M, Teachey D, Mullighan CG, Stegmaier K, Evans WE, Yu J, Yang JJ. Gocho Y, et al. Among authors: smart b. Nat Cancer. 2021 Mar;2(3):284-299. doi: 10.1038/s43018-020-00167-4. Epub 2021 Jan 21. Nat Cancer. 2021. PMID: 34151288 Free PMC article.
Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
Alcock LJ, Chang Y, Jarusiewicz JA, Actis M, Nithianantham S, Mayasundari A, Min J, Maxwell D, Hunt J, Smart B, Yang JJ, Nishiguchi G, Fischer M, Mullighan CG, Rankovic Z. Alcock LJ, et al. Among authors: smart b. ACS Med Chem Lett. 2022 Feb 21;13(3):475-482. doi: 10.1021/acsmedchemlett.1c00650. eCollection 2022 Mar 10. ACS Med Chem Lett. 2022. PMID: 35300081 Free PMC article.
Preclinical evaluation of proteolytic targeting of LCK as a therapeutic approach in T cell acute lymphoblastic leukemia.
Hu J, Jarusiewicz J, Du G, Nishiguchi G, Yoshimura S, Panetta JC, Li Z, Min J, Yang L, Chepyala D, Actis M, Reyes N, Smart B, Pui CH, Teachey DT, Rankovic Z, Yang JJ. Hu J, et al. Among authors: smart b. Sci Transl Med. 2022 Aug 24;14(659):eabo5228. doi: 10.1126/scitranslmed.abo5228. Epub 2022 Aug 24. Sci Transl Med. 2022. PMID: 36001679 Free PMC article.
Epigenetic activation of the FLT3 gene by ZNF384 fusion confers a therapeutic susceptibility in acute lymphoblastic leukemia.
Zhao X, Wang P, Diedrich JD, Smart B, Reyes N, Yoshimura S, Zhang J, Yang W, Barnett K, Xu B, Li Z, Huang X, Yu J, Crews K, Yeoh AEJ, Konopleva M, Wei CL, Pui CH, Savic D, Yang JJ. Zhao X, et al. Among authors: smart b. Nat Commun. 2022 Sep 14;13(1):5401. doi: 10.1038/s41467-022-33143-w. Nat Commun. 2022. PMID: 36104354 Free PMC article.
Ex vivo Drug Sensitivity Imaging-based Platform for Primary Acute Lymphoblastic Leukemia Cells.
Rowland L, Smart B, Brown A, Dettorre GM, Gocho Y, Hunt J, Yang W, Yoshimura S, Reyes N, Du G, John A, Maxwell D, Stock W, Kornblau S, Relling MV, Inaba H, Pui CH, Bourquin JP, Karol SE, Mullighan CG, Evans WE, Yang JJ, Crews KR. Rowland L, et al. Among authors: smart b. Bio Protoc. 2023 Aug 5;13(15):e4731. doi: 10.21769/BioProtoc.4731. eCollection 2023 Aug 5. Bio Protoc. 2023. PMID: 37575398 Free PMC article.
385 results