Tang H - Search Results

1

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo.

Lai M, Zhang T, Chen H, Song P, Tong L, Chen J, Liu Y, Ning Y, Feng F, Li Y, Tang H, Chen Y, Fang Y, Lu X, Geng M, Ding K, Yu K, Ding J, Xie H. Lai M, et al. Among authors: tang h. J Cancer. 2023 Jan 1;14(1):152-162. doi: 10.7150/jca.77788. eCollection 2023. J Cancer. 2023. PMID: 36605493 Free PMC article.

2

TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery.

Xiang S, Song S, Tang H, Smaill JB, Wang A, Xie H, Lu X. Xiang S, et al. Among authors: tang h. Drug Discov Today. 2021 Oct;26(10):2445-2455. doi: 10.1016/j.drudis.2021.05.016. Epub 2021 May 27. Drug Discov Today. 2021. PMID: 34051368 Review.

3

LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo.

Liu Y, Lai M, Li S, Wang Y, Feng F, Zhang T, Tong L, Zhang M, Chen H, Chen Y, Song P, Li Y, Bai G, Ning Y, Tang H, Fang Y, Chen Y, Lu X, Geng M, Ding K, Yu K, Xie H, Ding J. Liu Y, et al. Among authors: tang h. Cancer Sci. 2022 Feb;113(2):709-720. doi: 10.1111/cas.15229. Epub 2021 Dec 16. Cancer Sci. 2022. PMID: 34855271 Free PMC article.

4

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study.

Sun Y, Tang H, Wang X, Feng F, Fan T, Zhao D, Xiong B, Xie H, Liu T. Sun Y, et al. Among authors: tang h. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1411-1425. doi: 10.1080/14756366.2022.2076674. J Enzyme Inhib Med Chem. 2022. PMID: 35587686 Free PMC article.

5

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK.

Song P, Bai G, Chan S, Zhang T, Tong L, Su Y, Shen Y, Chen Y, Liu Y, Lai M, Ning Y, Tang H, Fang Y, Chen Y, Ding K, Ding J, Xie H. Song P, et al. Among authors: tang h. Front Pharmacol. 2022 Dec 15;13:1071114. doi: 10.3389/fphar.2022.1071114. eCollection 2022. Front Pharmacol. 2022. PMID: 36588692 Free PMC article.

6

Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors.

Song S, Tang H, Ran T, Fang F, Tong L, Chen H, Xie H, Lu X. Song S, et al. Among authors: tang h. Eur J Med Chem. 2023 Feb 5;247:115034. doi: 10.1016/j.ejmech.2022.115034. Epub 2022 Dec 22. Eur J Med Chem. 2023. PMID: 36603506

7

Development of a series of quinazoline-2,5-diamine derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.

Shi H, Tang H, Li Y, Chen D, Liu T, Chen Y, Wang X, Chen L, Wang Y, Xie H, Xiong B. Shi H, et al. Among authors: tang h. Eur J Med Chem. 2023 Feb 15;248:115064. doi: 10.1016/j.ejmech.2022.115064. Epub 2022 Dec 30. Eur J Med Chem. 2023. PMID: 36621137

8

Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors.

Zhang J, Li Y, Tang H, Zhou Q, Tong L, Ding J, Xie H, Xiong B, Liu T. Zhang J, et al. Among authors: tang h. Bioorg Chem. 2023 Nov;140:106811. doi: 10.1016/j.bioorg.2023.106811. Epub 2023 Aug 26. Bioorg Chem. 2023. PMID: 37659145

9

A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy.

Liu Y, Tong L, Zhang M, Zhang Q, Liu Q, Feng F, Li Y, Lai M, Tang H, Chen Y, Geng M, Duan W, Ding J, Xie H. Liu Y, et al. Among authors: tang h. Cancer Commun (Lond). 2024 Mar;44(3):438-442. doi: 10.1002/cac2.12521. Epub 2024 Feb 9. Cancer Commun (Lond). 2024. PMID: 38335159 Free PMC article. No abstract available.

10

A Novel IRAK4 Inhibitor DW18134 Ameliorates Peritonitis and Inflammatory Bowel Disease.

Huang Y, Ning Y, Chen Z, Song P, Tang H, Shi W, Wan Z, Huang G, Liu Q, Chen Y, Zhou Y, Li Y, Zhan Z, Ding J, Duan W, Xie H. Huang Y, et al. Among authors: tang h. Molecules. 2024 Apr 16;29(8):1803. doi: 10.3390/molecules29081803. Molecules. 2024. PMID: 38675622 Free PMC article.

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