Yang K - Search Results

1

Design, synthesis and biological evaluation of novel 9-N-substituted-13-alkylberberine derivatives from Chinese medicine as anti-hepatocellular carcinoma agents.

Chen J, Duan Y, Yang K, Wang J, Yan J, Gu C, Wang S, Zhu Z, Liu EH, Xu J. Chen J, et al. Among authors: yang k. Bioorg Med Chem. 2023 Feb 1;79:117156. doi: 10.1016/j.bmc.2023.117156. Epub 2023 Jan 8. Bioorg Med Chem. 2023. PMID: 36640595

2

Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.

Yang K, Yu J, Nong K, Wang Y, Niu A, Chen W, Dong J, Wang J. Yang K, et al. J Med Chem. 2020 Feb 13;63(3):961-974. doi: 10.1021/acs.jmedchem.9b00739. Epub 2020 Jan 28. J Med Chem. 2020. PMID: 31944697

3

Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors.

Xu Y, Jian MM, Han C, Yang K, Bai LG, Cao F, Ma ZY. Xu Y, et al. Among authors: yang k. Bioorg Med Chem Lett. 2020 Mar 15;30(6):126985. doi: 10.1016/j.bmcl.2020.126985. Epub 2020 Jan 24. Bioorg Med Chem Lett. 2020. PMID: 32008906

4

Synthesis and biological evaluation of novel pyrazoline derivatives containing indole skeleton as anti-cancer agents targeting topoisomerase II.

Song Y, Feng S, Feng J, Dong J, Yang K, Liu Z, Qiao X. Song Y, et al. Among authors: yang k. Eur J Med Chem. 2020 Aug 15;200:112459. doi: 10.1016/j.ejmech.2020.112459. Epub 2020 May 21. Eur J Med Chem. 2020. PMID: 32502865

5

Development of indole-2-carbonyl piperazine urea derivatives as selective FAAH inhibitors for efficient treatment of depression and pain.

Shang Y, Wang M, Hao Q, Meng T, Li L, Shi J, Yang G, Zhang Z, Yang K, Wang J. Shang Y, et al. Among authors: yang k, yang g. Bioorg Chem. 2022 Nov;128:106031. doi: 10.1016/j.bioorg.2022.106031. Epub 2022 Jul 16. Bioorg Chem. 2022. PMID: 36037600

6

Discovery of selective covalent cathepsin K inhibitors containing novel 4-cyanopyrimidine warhead based on quantum chemical calculations and binding mode analysis.

Jia Y, Wang K, Wang H, Zhang B, Yang K, Zhang Z, Dong H, Wang J. Jia Y, et al. Among authors: yang k. Bioorg Med Chem. 2022 Nov 15;74:117053. doi: 10.1016/j.bmc.2022.117053. Epub 2022 Oct 9. Bioorg Med Chem. 2022. PMID: 36270112

7

Discovery of Novel N-Hydroxy-1,2,4-oxadiazole-5-formamides as ASM Direct Inhibitors for the Treatment of Atherosclerosis.

Yang K, Nong K, Xu F, Chen Y, Yu J, Lin L, Hu X, Wang Y, Li T, Dong J, Wang J. Yang K, et al. J Med Chem. 2023 Feb 23;66(4):2681-2698. doi: 10.1021/acs.jmedchem.2c01643. Epub 2023 Feb 14. J Med Chem. 2023. PMID: 36786607

8

Design, synthesis and biological evaluation of dual Topo II/HDAC inhibitors bearing pyrimido[5,4-b]indole and pyrazolo[3,4-d]pyrimidine motifs.

Zhao M, Yang K, Zhu X, Gao T, Yu W, Liu H, You Z, Liu Z, Qiao X, Song Y. Zhao M, et al. Among authors: yang k. Eur J Med Chem. 2023 Apr 5;252:115303. doi: 10.1016/j.ejmech.2023.115303. Epub 2023 Mar 24. Eur J Med Chem. 2023. PMID: 36996717

9

Design and synthesis of a novel class of PDE4 inhibitors with antioxidant properties as bifunctional agents for the potential treatment of COPD.

Wang Y, Wang H, Yang G, Hao Q, Yang K, Shen H, Wang Y, Wang J. Wang Y, et al. Among authors: yang k, yang g. Eur J Med Chem. 2023 Aug 5;256:115374. doi: 10.1016/j.ejmech.2023.115374. Epub 2023 Apr 24. Eur J Med Chem. 2023. PMID: 37150057

10

Design, synthesis, antitumor activity, and molecular dynamics simulations of novel sphingosine kinase 2 inhibitors.

Wang S, Huo Y, Zhang J, Li L, Cao F, Song Y, Zhang Y, Yang K. Wang S, et al. Among authors: yang k. Bioorg Med Chem. 2023 Oct 1;93:117441. doi: 10.1016/j.bmc.2023.117441. Epub 2023 Aug 14. Bioorg Med Chem. 2023. PMID: 37586181

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