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Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as "Doorstop" for NADPH Entry.
Silvestri I, Lyu H, Fata F, Boumis G, Miele AE, Ardini M, Ippoliti R, Bellelli A, Jadhav A, Lea WA, Simeonov A, Cheng Q, Arnér ESJ, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Silvestri I, et al. Among authors: fata f. ACS Chem Biol. 2018 Aug 17;13(8):2190-2202. doi: 10.1021/acschembio.8b00349. Epub 2018 Jun 11. ACS Chem Biol. 2018. PMID: 29800515 Free PMC article.
Ectopic suicide inhibition of thioredoxin glutathione reductase.
Silvestri I, Lyu H, Fata F, Banta PR, Mattei B, Ippoliti R, Bellelli A, Pitari G, Ardini M, Petukhova V, Thatcher GRJ, Petukhov PA, Williams DL, Angelucci F. Silvestri I, et al. Among authors: fata f. Free Radic Biol Med. 2020 Feb 1;147:200-211. doi: 10.1016/j.freeradbiomed.2019.12.019. Epub 2019 Dec 20. Free Radic Biol Med. 2020. PMID: 31870799 Free PMC article.
The folding and aggregation properties of a single KH-domain protein: Ribosome binding factor A (RbfA) from Pseudomonas aeruginosa.
Santorelli D, Rocchio S, Fata F, Silvestri I, Angelucci F, Imperi F, Marasco D, Diaferia C, Gigli L, Demitri N, Federici L, Di Matteo A, Travaglini-Allocatelli C. Santorelli D, et al. Among authors: fata f. Biochim Biophys Acta Gen Subj. 2021 Feb;1865(2):129780. doi: 10.1016/j.bbagen.2020.129780. Epub 2020 Nov 4. Biochim Biophys Acta Gen Subj. 2021. PMID: 33157160
Non-covalent inhibitors of thioredoxin glutathione reductase with schistosomicidal activity in vivo.
Petukhova VZ, Aboagye SY, Ardini M, Lullo RP, Fata F, Byrne ME, Gabriele F, Martin LM, Harding LNM, Gone V, Dangi B, Lantvit DD, Nikolic D, Ippoliti R, Effantin G, Ling WL, Johnson JJ, Thatcher GRJ, Angelucci F, Williams DL, Petukhov PA. Petukhova VZ, et al. Among authors: fata f. Nat Commun. 2023 Jun 22;14(1):3737. doi: 10.1038/s41467-023-39444-y. Nat Commun. 2023. PMID: 37349300 Free PMC article.
46 results