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Page 1
Isolation of extracellular fluids reveals novel secreted bioactive proteins from muscle and fat tissues.
Mittenbühler MJ, Jedrychowski MP, Van Vranken JG, Sprenger HG, Wilensky S, Dumesic PA, Sun Y, Tartaglia A, Bogoslavski D, A M, Xiao H, Blackmore KA, Reddy A, Gygi SP, Chouchani ET, Spiegelman BM. Mittenbühler MJ, et al. Cell Metab. 2023 Mar 7;35(3):535-549.e7. doi: 10.1016/j.cmet.2022.12.014. Epub 2023 Jan 20. Cell Metab. 2023. PMID: 36681077 Free PMC article.
Amelioration of pathologic α-synuclein-induced Parkinson's disease by irisin.
Kam TI, Park H, Chou SC, Van Vranken JG, Mittenbühler MJ, Kim H, A M, Choi YR, Biswas D, Wang J, Shin Y, Loder A, Karuppagounder SS, Wrann CD, Dawson VL, Spiegelman BM, Dawson TM. Kam TI, et al. Among authors: mittenbuhler mj. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2204835119. doi: 10.1073/pnas.2204835119. Epub 2022 Aug 31. Proc Natl Acad Sci U S A. 2022. PMID: 36044549 Free PMC article.
Irisin acts through its integrin receptor in a two-step process involving extracellular Hsp90α.
A M, Wales TE, Zhou H, Draga-Coletă SV, Gorgulla C, Blackmore KA, Mittenbühler MJ, Kim CR, Bogoslavski D, Zhang Q, Wang ZF, Jedrychowski MP, Seo HS, Song K, Xu AZ, Sebastian L, Gygi SP, Arthanari H, Dhe-Paganon S, Griffin PR, Engen JR, Spiegelman BM. A M, et al. Among authors: mittenbuhler mj. Mol Cell. 2023 Jun 1;83(11):1903-1920.e12. doi: 10.1016/j.molcel.2023.05.008. Mol Cell. 2023. PMID: 37267907 Free PMC article.
Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Sprenger HG, Mittenbühler MJ, Sun Y, Van Vranken JG, Schindler S, Jayaraj A, Khetarpal SA, Vargas-Castillo A, Puszynska AM, Spinelli JB, Armani A, Kunchok T, Ryback B, Seo HS, Song K, Sebastian L, O'Young C, Braithwaite C, Dhe-Paganon S, Burger N, Mills EL, Gygi SP, Arthanari H, Chouchani ET, Sabatini DM, Spiegelman BM. Sprenger HG, et al. Among authors: mittenbuhler mj. bioRxiv [Preprint]. 2024 Apr 10:2024.04.10.588849. doi: 10.1101/2024.04.10.588849. bioRxiv. 2024. PMID: 38645260 Free PMC article. Preprint.
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.
Ducommun S, Jannig PR, Cervenka I, Murgia M, Mittenbühler MJ, Chernogubova E, Dias JM, Jude B, Correia JC, Van Vranken JG, Ocana-Santero G, Porsmyr-Palmertz M, McCann Haworth S, Martínez-Redondo V, Liu Z, Carlström M, Mann M, Lanner JT, Teixeira AI, Maegdefessel L, Spiegelman BM, Ruas JL. Ducommun S, et al. Among authors: mittenbuhler mj. Mol Metab. 2024 Apr;82:101912. doi: 10.1016/j.molmet.2024.101912. Epub 2024 Mar 6. Mol Metab. 2024. PMID: 38458566 Free PMC article.
A comprehensive landscape of the zinc-regulated human proteome.
Burger N, Mittenbühler MJ, Xiao H, Shin S, Bozi LHM, Wei S, Sprenger HG, Sun Y, Zhu Y, Darabedian N, Petrocelli JJ, Muro PL, Che J, Chouchani ET. Burger N, et al. Among authors: mittenbuhler mj. bioRxiv [Preprint]. 2024 Jan 5:2024.01.04.574225. doi: 10.1101/2024.01.04.574225. bioRxiv. 2024. PMID: 38260676 Free PMC article. Preprint.