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Immunological and metabolic characteristics of the Omicron variants infection.
Geng J, Yang X, Wang K, Wang K, Chen R, Chen ZN, Qin C, Wu G, Wang Y, Xu K, Du P, Liu J, Chen S, Zhang T, Sun X, Guo T, Shi Y, Zhang Z, Wei D, Lin P, Wang Q, Yuan J, Qu J, Zou J, Liu Y, Lu H, Zhu P, Bian H, Chen L. Geng J, et al. Among authors: yang x. Signal Transduct Target Ther. 2023 Jan 21;8(1):42. doi: 10.1038/s41392-022-01265-8. Signal Transduct Target Ther. 2023. PMID: 36681668 Free PMC article.
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
Wang K, Chen W, Zhang Z, Deng Y, Lian JQ, Du P, Wei D, Zhang Y, Sun XX, Gong L, Yang X, He L, Zhang L, Yang Z, Geng JJ, Chen R, Zhang H, Wang B, Zhu YM, Nan G, Jiang JL, Li L, Wu J, Lin P, Huang W, Xie L, Zheng ZH, Zhang K, Miao JL, Cui HY, Huang M, Zhang J, Fu L, Yang XM, Zhao Z, Sun S, Gu H, Wang Z, Wang CF, Lu Y, Liu YY, Wang QY, Bian H, Zhu P, Chen ZN. Wang K, et al. Among authors: yang xm, yang x, yang z. Signal Transduct Target Ther. 2020 Dec 4;5(1):283. doi: 10.1038/s41392-020-00426-x. Signal Transduct Target Ther. 2020. PMID: 33277466 Free PMC article.
Safety and efficacy of meplazumab in healthy volunteers and COVID-19 patients: a randomized phase 1 and an exploratory phase 2 trial.
Bian H, Zheng ZH, Wei D, Wen A, Zhang Z, Lian JQ, Kang WZ, Hao CQ, Wang J, Xie RH, Dong K, Xia JL, Miao JL, Kang W, Li G, Zhang D, Zhang M, Sun XX, Ding L, Zhang K, Jia J, Ding J, Li Z, Jia Y, Liu LN, Zhang Z, Gao ZW, Du H, Yao N, Wang Q, Wang K, Geng JJ, Wang B, Guo T, Chen R, Zhu YM, Wang LJ, He Q, Yao RR, Shi Y, Yang XM, Zhou JS, Ma YN, Wang YT, Liang X, Huo F, Wang Z, Zhang Y, Yang X, Zhang Y, Gao LH, Wang L, Chen XC, Tang H, Liu SS, Wang QY, Chen ZN, Zhu P. Bian H, et al. Among authors: yang xm, yang x. Signal Transduct Target Ther. 2021 May 17;6(1):194. doi: 10.1038/s41392-021-00603-6. Signal Transduct Target Ther. 2021. PMID: 34001849 Free PMC article. Clinical Trial.
CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta, alpha, beta, and gamma.
Geng J, Chen L, Yuan Y, Wang K, Wang Y, Qin C, Wu G, Chen R, Zhang Z, Wei D, Du P, Zhang J, Lin P, Zhang K, Deng Y, Xu K, Liu J, Sun X, Guo T, Yang X, Wu J, Jiang J, Li L, Zhang K, Wang Z, Zhang J, Yan Q, Zhu H, Zheng Z, Miao J, Fu X, Yang F, Chen X, Tang H, Zhang Y, Shi Y, Zhu Y, Pei Z, Huo F, Liang X, Wang Y, Wang Q, Xie W, Li Y, Shi M, Bian H, Zhu P, Chen ZN. Geng J, et al. Among authors: yang f, yang x. Signal Transduct Target Ther. 2021 Sep 25;6(1):347. doi: 10.1038/s41392-021-00760-8. Signal Transduct Target Ther. 2021. PMID: 34564690 Free PMC article.
CD147 contributes to SARS-CoV-2-induced pulmonary fibrosis.
Wu J, Chen L, Qin C, Huo F, Liang X, Yang X, Zhang K, Lin P, Liu J, Feng Z, Zhou J, Pei Z, Wang Y, Sun XX, Wang K, Geng J, Zheng Z, Fu X, Liu M, Wang Q, Zhang Z, Bian H, Zhu P, Chen ZN. Wu J, et al. Among authors: yang x. Signal Transduct Target Ther. 2022 Nov 25;7(1):382. doi: 10.1038/s41392-022-01230-5. Signal Transduct Target Ther. 2022. PMID: 36424379 Free PMC article.
Meplazumab in hospitalized adults with severe COVID-19 (DEFLECT): a multicenter, seamless phase 2/3, randomized, third-party double-blind clinical trial.
Bian H, Chen L, Zheng ZH, Sun XX, Geng JJ, Chen R, Wang K, Yang X, Chen SR, Chen SY, Xie RH, Zhang K, Miao JL, Jia JF, Tang H, Liu SS, Shi HW, Yang Y, Chen XC, Malhotra V, Nasir N, Khanum I, Mahmood F, Hamid S, Stadnik CMB, Itinose K, de Oliveira CCC, Dusilek C, Rivabem L, Cavalcante AJW, Lopes SS, Saporito WF, Fucci FJC, Simon-Campos JA, Wang L, Liu LN, Wang QY, Wei D, Zhang Z, Chen ZN, Zhu P. Bian H, et al. Among authors: yang x, yang y. Signal Transduct Target Ther. 2023 Jan 30;8(1):46. doi: 10.1038/s41392-023-01323-9. Signal Transduct Target Ther. 2023. PMID: 36717539 Free PMC article. Clinical Trial.
Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity.
Zhai Y, Chen L, Zhao Q, Zheng ZH, Chen ZN, Bian H, Yang X, Lu HY, Lin P, Chen X, Chen R, Sun HY, Fan LN, Zhang K, Wang B, Sun XX, Feng Z, Zhu YM, Zhou JS, Chen SR, Zhang T, Chen SY, Chen JJ, Zhang K, Wang Y, Chang Y, Zhang R, Zhang B, Wang LJ, Li XM, He Q, Yang XM, Nan G, Xie RH, Yang L, Yang JH, Zhu P. Zhai Y, et al. Among authors: yang xm, yang jh, yang l, yang x. Science. 2023 Mar 17;379(6637):eabg2482. doi: 10.1126/science.abg2482. Epub 2023 Mar 17. Science. 2023. PMID: 36927018
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