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Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission.
Tukwasibwe S, Lewis SN, Taremwa Y, van der Ploeg K, Press KD, Ty M, Namirimu Nankya F, Musinguzi K, Nansubuga E, Bach F, Chamai M, Okitwi M, Tumusiime G, Nakimuli A, Colucci F, Kamya MR, Nankabirwa JI, Arinaitwe E, Greenhouse B, Dorsey G, Rosenthal PJ, Ssewanyana I, Jagannathan P. Tukwasibwe S, et al. Among authors: musinguzi k. Clin Transl Immunology. 2024 Nov 1;13(11):e70005. doi: 10.1002/cti2.70005. eCollection 2024. Clin Transl Immunology. 2024. PMID: 39493859 Free PMC article.
Clinical immunity to malaria involves epigenetic reprogramming of innate immune cells.
Nideffer J, Ty M, Donato M, John R, Kajubi R, Ji X, Nankya F, Musinguzi K, Press KD, Yang N, Camanag K, Greenhouse B, Kamya M, Feeney ME, Dorsey G, Utz PJ, Pulendran B, Khatri P, Jagannathan P. Nideffer J, et al. Among authors: musinguzi k. PNAS Nexus. 2024 Aug 6;3(8):pgae325. doi: 10.1093/pnasnexus/pgae325. eCollection 2024 Aug. PNAS Nexus. 2024. PMID: 39161730 Free PMC article.
MALARIA-WHY DO MOSTLY CHILDREN GET SICK?
Garza R, Huson M, Garcia A, Gonzalez B, Musinguzi K, Nagaragere A, Nansubuga E, Zedi M, Bunnik EM, Bol S. Garza R, et al. Among authors: musinguzi k. Front Young Minds. 2024 Feb;12:1305938. doi: 10.3389/frym.2024.1305938. Epub 2024 Feb 1. Front Young Minds. 2024. PMID: 38362230 Free PMC article.
Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria.
Kirosingh AS, Delmastro A, Kakuru A, van der Ploeg K, Bhattacharya S, Press KD, Ty M, Parte L, Kizza J, Muhindo M, Devachanne S, Gamain B, Nankya F, Musinguzi K, Rosenthal PJ, Feeney ME, Kamya M, Dorsey G, Jagannathan P. Kirosingh AS, et al. Among authors: musinguzi k. EBioMedicine. 2023 Sep;95:104772. doi: 10.1016/j.ebiom.2023.104772. Epub 2023 Aug 25. EBioMedicine. 2023. PMID: 37634385 Free PMC article.
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Ty M, Sun S, Callaway PC, Rek J, Press KD, van der Ploeg K, Nideffer J, Hu Z, Klemm S, Greenleaf W, Donato M, Tukwasibwe S, Arinaitwe E, Nankya F, Musinguzi K, Andrew D, de la Parte L, Mori DM, Lewis SN, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Blish C, Utz PJ, Khatri P, Dorsey G, Kamya M, Boyle M, Feeney M, Ssewanyana I, Jagannathan P. Ty M, et al. Among authors: musinguzi k. Sci Transl Med. 2023 Jan 25;15(680):eadd9012. doi: 10.1126/scitranslmed.add9012. Epub 2023 Jan 25. Sci Transl Med. 2023. PMID: 36696483 Free PMC article.
In Utero Activation of Natural Killer Cells in Congenital Cytomegalovirus Infection.
Vaaben AV, Levan J, Nguyen CBT, Callaway PC, Prahl M, Warrier L, Nankya F, Musinguzi K, Kakuru A, Muhindo MK, Dorsey G, Kamya MR, Feeney ME. Vaaben AV, et al. Among authors: musinguzi k. J Infect Dis. 2022 Sep 4;226(4):566-575. doi: 10.1093/infdis/jiac307. J Infect Dis. 2022. PMID: 35876164 Free PMC article.
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Chan JA, Loughland JR, de la Parte L, Okano S, Ssewanyana I, Nalubega M, Nankya F, Musinguzi K, Rek J, Arinaitwe E, Tipping P, Bourke P, Andrew D, Dooley N, SheelaNair A, Wines BD, Hogarth PM, Beeson JG, Greenhouse B, Dorsey G, Kamya M, Hartel G, Minigo G, Feeney M, Jagannathan P, Boyle MJ. Chan JA, et al. Among authors: musinguzi k. Nat Commun. 2022 Jul 18;13(1):4159. doi: 10.1038/s41467-022-31880-6. Nat Commun. 2022. PMID: 35851033 Free PMC article.
Exposure to pesticides in utero impacts the fetal immune system and response to vaccination in infancy.
Prahl M, Odorizzi P, Gingrich D, Muhindo M, McIntyre T, Budker R, Jagannathan P, Farrington L, Nalubega M, Nankya F, Sikyomu E, Musinguzi K, Naluwu K, Auma A, Kakuru A, Kamya MR, Dorsey G, Aweeka F, Feeney ME. Prahl M, et al. Among authors: musinguzi k. Nat Commun. 2021 Jan 8;12(1):132. doi: 10.1038/s41467-020-20475-8. Nat Commun. 2021. PMID: 33420104 Free PMC article.
Opsonized antigen activates Vδ2+ T cells via CD16/FCγRIIIa in individuals with chronic malaria exposure.
Farrington LA, Callaway PC, Vance HM, Baskevitch K, Lutz E, Warrier L, McIntyre TI, Budker R, Jagannathan P, Nankya F, Musinguzi K, Nalubega M, Sikyomu E, Naluwu K, Arinaitwe E, Dorsey G, Kamya MR, Feeney ME. Farrington LA, et al. Among authors: musinguzi k. PLoS Pathog. 2020 Oct 21;16(10):e1008997. doi: 10.1371/journal.ppat.1008997. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33085728 Free PMC article.
17 results