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A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A.
Simon M, Yang J, Gigas J, Earley EJ, Hillpot E, Zhang L, Zagorulya M, Tombline G, Gilbert M, Yuen SL, Pope A, Van Meter M, Emmrich S, Firsanov D, Athreya A, Biashad SA, Han J, Ryu S, Tare A, Zhu Y, Hudgins A, Atzmon G, Barzilai N, Wolfe A, Moody K, Garcia BA, Robbins PD, Vijg J, Seluanov A, Suh Y, Gorbunova V. Simon M, et al. EMBO J. 2023 Feb 1;42(3):e113326. doi: 10.15252/embj.2022113326. EMBO J. 2023. PMID: 36722290 Free PMC article.
SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species.
Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V. Tian X, et al. Among authors: simon m. Cell. 2019 Apr 18;177(3):622-638.e22. doi: 10.1016/j.cell.2019.03.043. Cell. 2019. PMID: 31002797 Free PMC article.
DNA damage and repair in age-related inflammation.
Zhao Y, Simon M, Seluanov A, Gorbunova V. Zhao Y, et al. Among authors: simon m. Nat Rev Immunol. 2023 Feb;23(2):75-89. doi: 10.1038/s41577-022-00751-y. Epub 2022 Jul 13. Nat Rev Immunol. 2023. PMID: 35831609 Free PMC article. Review.
cGAS deficient mice display premature aging associated with de-repression of LINE1 elements and inflammation.
Martinez JC, Morandini F, Fitzgibbons L, Sieczkiewicz N, Bae SJ, Meadow ME, Hillpot E, Cutting J, Paige V, Biashad SA, Simon M, Sedivy J, Seluanov A, Gorbunova V. Martinez JC, et al. Among authors: simon m. bioRxiv [Preprint]. 2024 Oct 11:2024.10.10.617645. doi: 10.1101/2024.10.10.617645. bioRxiv. 2024. PMID: 39416083 Free PMC article. Preprint.
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V. Simon M, et al. Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7. Cell Metab. 2019. PMID: 30853213 Free PMC article.
Accurate Proteomewide Measurement of Methionine Oxidation in Aging Mouse Brains.
Bettinger JQ, Simon M, Korotkov A, Welle KA, Hryhorenko JR, Seluanov A, Gorbunova V, Ghaemmaghami S. Bettinger JQ, et al. Among authors: simon m. J Proteome Res. 2022 Jun 3;21(6):1495-1509. doi: 10.1021/acs.jproteome.2c00127. Epub 2022 May 18. J Proteome Res. 2022. PMID: 35584362 Free PMC article.
6,519 results