Handlogten MW - Search Results

1

Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19.

Handlogten MW, Bosley S, Dunn S, Zhu J, Lee-O'Brien A, Li L, Therres J, Chakrabarti L, Khanal B, Mowery R, Arumugam S, Klover J, Taleb M, Reier J, Hatton D, Schmelzer A. Handlogten MW, et al. Biotechnol Bioeng. 2023 Feb 1. doi: 10.1002/bit.28336. Online ahead of print. Biotechnol Bioeng. 2023. PMID: 36722717

2

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.

Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M. Chung WK, et al. Biotechnol Bioeng. 2017 Jun;114(6):1264-1274. doi: 10.1002/bit.26265. Epub 2017 Mar 6. Biotechnol Bioeng. 2017. PMID: 28186329 Free PMC article.

3

Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing.

Handlogten MW, Zhu M, Ahuja S. Handlogten MW, et al. Biotechnol Bioeng. 2017 Jul;114(7):1469-1477. doi: 10.1002/bit.26278. Epub 2017 Mar 20. Biotechnol Bioeng. 2017. PMID: 28262915

4

Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process.

Handlogten MW, Lee-O'Brien A, Roy G, Levitskaya SV, Venkat R, Singh S, Ahuja S. Handlogten MW, et al. Biotechnol Bioeng. 2018 Jan;115(1):126-138. doi: 10.1002/bit.26460. Biotechnol Bioeng. 2018. PMID: 28941283

5

Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Swope N, Chung WK, Cao M, Motabar D, Liu D, Ahuja S, Handlogten M. Swope N, et al. Biotechnol Bioeng. 2020 Apr;117(4):1063-1071. doi: 10.1002/bit.27264. Epub 2020 Jan 23. Biotechnol Bioeng. 2020. PMID: 31930476 Free PMC article.

6

Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction.

Handlogten MW, Wang J, Ahuja S. Handlogten MW, et al. Biotechnol Bioeng. 2020 May;117(5):1329-1336. doi: 10.1002/bit.27281. Epub 2020 Jan 29. Biotechnol Bioeng. 2020. PMID: 31956991

7

Engineering redox sensors into CHO cells enables near-real-time quantification of intracellular redox in bioprocesses.

McFarland KS, Zhu J, Sinharoy P, Betenbaugh MJ, Handlogten MW. McFarland KS, et al. Among authors: handlogten mw. Biotechnol Bioeng. 2022 Jun;119(6):1439-1449. doi: 10.1002/bit.28067. Epub 2022 Mar 3. Biotechnol Bioeng. 2022. PMID: 35182429

8

Elevated endoplasmic reticulum pH is associated with high growth and bisAb aggregation in CHO cells.

McFarland KS, Hegadorn K, Betenbaugh MJ, Handlogten MW. McFarland KS, et al. Among authors: handlogten mw. Biotechnol Bioeng. 2024 Oct 22. doi: 10.1002/bit.28866. Online ahead of print. Biotechnol Bioeng. 2024. PMID: 39435744

9

Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production.

Sinharoy P, McFarland KS, Majewska NI, Betenbaugh MJ, Handlogten MW. Sinharoy P, et al. Among authors: handlogten mw. Curr Opin Biotechnol. 2021 Oct;71:49-54. doi: 10.1016/j.copbio.2021.06.017. Epub 2021 Jul 7. Curr Opin Biotechnol. 2021. PMID: 34243034 Review.

10

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region.

Handlogten MW, Peng L, Christian EA, Xu W, Lin S, Venkat R, Dall'Acqua W, Ahuja S. Handlogten MW, et al. MAbs. 2020 Jan-Dec;12(1):1779974. doi: 10.1080/19420862.2020.1779974. MAbs. 2020. PMID: 32633193 Free PMC article.

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