Brewitz L - Search Results

1

Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.

Brewitz L, Dumjahn L, Zhao Y, Owen CD, Laidlaw SM, Malla TR, Nguyen D, Lukacik P, Salah E, Crawshaw AD, Warren AJ, Trincao J, Strain-Damerell C, Carroll MW, Walsh MA, Schofield CJ. Brewitz L, et al. J Med Chem. 2023 Feb 23;66(4):2663-2680. doi: 10.1021/acs.jmedchem.2c01627. Epub 2023 Feb 9. J Med Chem. 2023. PMID: 36757959 Free PMC article.

2

Catalytic generation of α-CF3 enolate: direct catalytic asymmetric Mannich-type reaction of α-CF3 amide.

Yin L, Brewitz L, Kumagai N, Shibasaki M. Yin L, et al. Among authors: brewitz l. J Am Chem Soc. 2014 Dec 31;136(52):17958-61. doi: 10.1021/ja511458k. Epub 2014 Dec 19. J Am Chem Soc. 2014. PMID: 25495289

3

Direct Catalytic Asymmetric Mannich-Type Reaction of Alkylamides.

Arteaga FA, Liu Z, Brewitz L, Chen J, Sun B, Kumagai N, Shibasaki M. Arteaga FA, et al. Among authors: brewitz l. Org Lett. 2016 May 20;18(10):2391-4. doi: 10.1021/acs.orglett.6b00879. Epub 2016 May 12. Org Lett. 2016. PMID: 27171610

4

Achiral Trisubstituted Thioureas as Secondary Ligands to Cu^I Catalysts: Direct Catalytic Asymmetric Addition of α-Fluoronitriles to Imines.

Balaji PV, Brewitz L, Kumagai N, Shibasaki M. Balaji PV, et al. Among authors: brewitz l. Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2644-2648. doi: 10.1002/anie.201812673. Epub 2018 Dec 12. Angew Chem Int Ed Engl. 2019. PMID: 30468281

5

Direct Catalytic Asymmetric Mannich-Type Reaction of α- and β-Fluorinated Amides.

Brewitz L, Arteaga FA, Yin L, Alagiri K, Kumagai N, Shibasaki M. Brewitz L, et al. J Am Chem Soc. 2015 Dec 23;137(50):15929-39. doi: 10.1021/jacs.5b11064. Epub 2015 Dec 10. J Am Chem Soc. 2015. PMID: 26652911

6

Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.

Pfeffer I, Brewitz L, Krojer T, Jensen SA, Kochan GT, Kershaw NJ, Hewitson KS, McNeill LA, Kramer H, Münzel M, Hopkinson RJ, Oppermann U, Handford PA, McDonough MA, Schofield CJ. Pfeffer I, et al. Among authors: brewitz l. Nat Commun. 2019 Oct 28;10(1):4910. doi: 10.1038/s41467-019-12711-7. Nat Commun. 2019. PMID: 31659163 Free PMC article.

7

Kinetic parameters of human aspartate/asparagine-β-hydroxylase suggest that it has a possible function in oxygen sensing.

Brewitz L, Tumber A, Schofield CJ. Brewitz L, et al. J Biol Chem. 2020 Jun 5;295(23):7826-7838. doi: 10.1074/jbc.RA119.012202. Epub 2020 Feb 26. J Biol Chem. 2020. PMID: 32107312 Free PMC article.

8

Synthesis of Novel Pyridine-Carboxylates as Small-Molecule Inhibitors of Human Aspartate/Asparagine-β-Hydroxylase.

Brewitz L, Tumber A, Thalhammer A, Salah E, Christensen KE, Schofield CJ. Brewitz L, et al. ChemMedChem. 2020 Jul 3;15(13):1139-1149. doi: 10.1002/cmdc.202000147. Epub 2020 May 26. ChemMedChem. 2020. PMID: 32330361 Free PMC article.

9

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors.

Brewitz L, Tumber A, Pfeffer I, McDonough MA, Schofield CJ. Brewitz L, et al. Sci Rep. 2020 May 26;10(1):8650. doi: 10.1038/s41598-020-65123-9. Sci Rep. 2020. PMID: 32457455 Free PMC article.

10

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.

Brewitz L, Tumber A, Zhang X, Schofield CJ. Brewitz L, et al. Bioorg Med Chem. 2020 Oct 15;28(20):115675. doi: 10.1016/j.bmc.2020.115675. Epub 2020 Aug 6. Bioorg Med Chem. 2020. PMID: 33069066 Free PMC article.

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