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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition.
Schwab A, Rao Z, Zhang J, Gollowitzer A, Siebenkäs K, Bindel N, D'Avanzo E, van Roey R, Hajjaj Y, Özel E, Armstark I, Bereuter L, Su F, Grander J, Bonyadi Rad E, Groenewoud A, Engel FB, Bell GW, Henry WS, Angeli JPF, Stemmler MP, Brabletz S, Koeberle A, Brabletz T. Schwab A, et al. Among authors: gollowitzer a. Nat Cell Biol. 2024 Sep;26(9):1470-1481. doi: 10.1038/s41556-024-01464-1. Epub 2024 Jul 15. Nat Cell Biol. 2024. PMID: 39009641 Free PMC article.
Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans.
Sharifi S, Chaudhari P, Martirosyan A, Eberhardt AO, Witt F, Gollowitzer A, Lange L, Woitzat Y, Okoli EM, Li H, Rahnis N, Kirkpatrick J, Werz O, Ori A, Koeberle A, Bierhoff H, Ermolaeva M. Sharifi S, et al. Among authors: gollowitzer a. Nat Commun. 2024 Feb 24;15(1):1702. doi: 10.1038/s41467-024-46037-w. Nat Commun. 2024. PMID: 38402241 Free PMC article.
Proteome Coverage after Simultaneous Proteo-Metabolome Liquid-Liquid Extraction.
van Pijkeren A, Egger AS, Hotze M, Zimmermann E, Kipura T, Grander J, Gollowitzer A, Koeberle A, Bischoff R, Thedieck K, Kwiatkowski M. van Pijkeren A, et al. Among authors: gollowitzer a. J Proteome Res. 2023 Mar 3;22(3):951-966. doi: 10.1021/acs.jproteome.2c00758. Epub 2023 Feb 10. J Proteome Res. 2023. PMID: 36763818 Free PMC article.
Rotational constriction of curcuminoids impacts 5-lipoxygenase and mPGES-1 inhibition and evokes a lipid mediator class switch in macrophages.
Rao Z, Caprioglio D, Gollowitzer A, Kretzer C, Imperio D, Collado JA, Waltl L, Lackner S, Appendino G, Muñoz E, Temml V, Werz O, Minassi A, Koeberle A. Rao Z, et al. Among authors: gollowitzer a. Biochem Pharmacol. 2022 Sep;203:115202. doi: 10.1016/j.bcp.2022.115202. Epub 2022 Aug 3. Biochem Pharmacol. 2022. PMID: 35932797 Free article.
PI(18:1/18:1) is a SCD1-derived lipokine that limits stress signaling.
Thürmer M, Gollowitzer A, Pein H, Neukirch K, Gelmez E, Waltl L, Wielsch N, Winkler R, Löser K, Grander J, Hotze M, Harder S, Döding A, Meßner M, Troisi F, Ardelt M, Schlüter H, Pachmayr J, Gutiérrez-Gutiérrez Ó, Rudolph KL, Thedieck K, Schulze-Späte U, González-Estévez C, Kosan C, Svatoš A, Kwiatkowski M, Koeberle A. Thürmer M, et al. Among authors: gollowitzer a. Nat Commun. 2022 May 27;13(1):2982. doi: 10.1038/s41467-022-30374-9. Nat Commun. 2022. PMID: 35624087 Free PMC article.
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.
Neukirch K, Alsabil K, Dinh CP, Bilancia R, Raasch M, Ville A, Cerqua I, Viault G, Bréard D, Pace S, Temml V, Brunner E, Jordan PM, Marques MC, Loeser K, Gollowitzer A, Permann S, Gerstmeier J, Lorkowski S, Stuppner H, Garscha U, Rodrigues T, Bernardes GJL, Schuster D, Séraphin D, Richomme P, Rossi A, Mosig AS, Roviezzo F, Werz O, Helesbeux JJ, Koeberle A. Neukirch K, et al. Among authors: gollowitzer a. J Med Chem. 2021 Aug 12;64(15):11496-11526. doi: 10.1021/acs.jmedchem.1c00806. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279935 Free PMC article.
Tnfaip2/exoc3-driven lipid metabolism is essential for stem cell differentiation and organ homeostasis.
Deb S, Felix DA, Koch P, Deb MK, Szafranski K, Buder K, Sannai M, Groth M, Kirkpatrick J, Pietsch S, Gollowitzer A, Groß A, Riemenschneider P, Koeberle A, González-Estévez C, Rudolph KL. Deb S, et al. Among authors: gollowitzer a. EMBO Rep. 2021 Jan 7;22(1):e49328. doi: 10.15252/embr.201949328. Epub 2020 Dec 10. EMBO Rep. 2021. PMID: 33300287 Free PMC article.
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