Jones LH - Search Results

1

Cereblon target validation using a covalent inhibitor of neosubstrate recruitment.

Dann GP, Liu H, Nowak RP, Jones LH. Dann GP, et al. Among authors: jones lh. Methods Enzymol. 2023;681:155-167. doi: 10.1016/bs.mie.2022.08.056. Epub 2022 Dec 30. Methods Enzymol. 2023. PMID: 36764755

2

Advancing targeted protein degrader discovery by measuring cereblon engagement in cells.

Zerfas BL, Huerta F, Liu H, Du G, Gray NS, Jones LH, Nowak RP. Zerfas BL, et al. Among authors: jones lh. Methods Enzymol. 2023;681:169-188. doi: 10.1016/bs.mie.2022.08.013. Epub 2022 Sep 26. Methods Enzymol. 2023. PMID: 36764756

3

ReSPONDINg TACtically, degrading strategically.

Zerfas BL, Jones LH. Zerfas BL, et al. Among authors: jones lh. Trends Pharmacol Sci. 2023 Nov;44(11):753-754. doi: 10.1016/j.tips.2023.08.010. Epub 2023 Sep 7. Trends Pharmacol Sci. 2023. PMID: 37689534

4

The promise of targeted protein degradation approaches.

Daniels DL, Sapkota GP, Jones LH. Daniels DL, et al. Among authors: jones lh. Trends Pharmacol Sci. 2023 Nov;44(11):746-749. doi: 10.1016/j.tips.2023.08.015. Epub 2023 Sep 28. Trends Pharmacol Sci. 2023. PMID: 37775456 No abstract available.

5

Targeted protein degraders: a call for collective action to advance safety assessment.

Jones LH, Mitchell CA, Loberg L, Pavkovic M, Rao M, Roberts R, Stamp K, Volak L, Wittwer MB, Pettit S. Jones LH, et al. Nat Rev Drug Discov. 2022 Jun;21(6):401-402. doi: 10.1038/d41573-022-00055-9. Nat Rev Drug Discov. 2022. PMID: 35322806 No abstract available.

6

Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.

Gechijian LN, Muncipinto G, Rettenmaier TJ, Labenski MT, Rusu V, Rosskamp L, Conway L, van Kalken D, Gross L, Iantosca G, Crotty W, Mathis R, Park H, Rabin B, Westgate C, Lyons M, Deshusses C, Brandon N, Brown DG, Blanchette HS, Pullen N, Jones LH, Barrish JC. Gechijian LN, et al. Among authors: jones lh. ACS Chem Biol. 2024 Nov 15;19(11):2372-2382. doi: 10.1021/acschembio.4c00571. Epub 2024 Oct 17. ACS Chem Biol. 2024. PMID: 39418577 Free PMC article.

7

Synthetic modification of protein surfaces to mediate induced-proximity pharmacology.

Jones LH. Jones LH. RSC Med Chem. 2024 Aug 9;15(9):2974-9. doi: 10.1039/d4md00388h. Online ahead of print. RSC Med Chem. 2024. PMID: 39185450 Free article.

8

Development of sulfonyl fluoride chemical probes to advance the discovery of cereblon modulators.

Liu Y, Nowak RP, Che J, Donovan KA, Huerta F, Liu H, Metivier RJ, Fischer ES, Jones LH. Liu Y, et al. Among authors: jones lh. RSC Med Chem. 2024 Jan 9;15(2):607-611. doi: 10.1039/d3md00652b. eCollection 2024 Feb 21. RSC Med Chem. 2024. PMID: 38389883

9

The Minimum Protein Staple? - Towards 'bio'-Baldwin's rules via inter-phosphosite linking in the MEK1 activation loop.

Galan SRG, Raj R, Mamalis D, Jones LH, Mohammed S, Davis BG. Galan SRG, et al. Among authors: jones lh. Chem Sci. 2023 Dec 1;15(4):1306-1317. doi: 10.1039/d3sc04631a. eCollection 2024 Jan 24. Chem Sci. 2023. PMID: 38274071 Free PMC article.

10

Covalent Stapling of the Cereblon Sensor Loop Histidine Using Sulfur-Heterocycle Exchange.

Cruite JT, Nowak RP, Donovan KA, Ficarro SB, Huang H, Liu H, Liu Y, Marto JA, Metivier RJ, Fischer ES, Jones LH. Cruite JT, et al. Among authors: jones lh. ACS Med Chem Lett. 2023 Oct 24;14(11):1576-1581. doi: 10.1021/acsmedchemlett.3c00371. eCollection 2023 Nov 9. ACS Med Chem Lett. 2023. PMID: 37974938 Free PMC article.

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