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Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy.
Palmeri JR, Lax BM, Peters JM, Duhamel L, Stinson JA, Santollani L, Lutz EA, Pinney W 3rd, Bryson BD, Wittrup KD. Palmeri JR, et al. Among authors: wittrup kd. bioRxiv [Preprint]. 2023 Feb 1:2023.01.30.526116. doi: 10.1101/2023.01.30.526116. bioRxiv. 2023. Update in: Nat Commun. 2024 Mar 1;15(1):1900. doi: 10.1038/s41467-024-45625-0 PMID: 36778460 Free PMC article. Updated. Preprint.
Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity.
Santollani L, Zhang YJ, Maiorino L, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Wittrup KD, Irvine DJ. Santollani L, et al. Among authors: wittrup kd. bioRxiv [Preprint]. 2024 Jan 3:2024.01.03.573641. doi: 10.1101/2024.01.03.573641. bioRxiv. 2024. Update in: Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7 PMID: 38260254 Free PMC article. Updated. Preprint.
Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs.
Stinson JA, Barbosa MMP, Sheen A, Momin N, Fink E, Hampel J, Selting K, Kamerer R, Bailey KL, Wittrup KD, Fan TM. Stinson JA, et al. Among authors: wittrup kd. bioRxiv [Preprint]. 2024 Feb 14:2024.02.12.579965. doi: 10.1101/2024.02.12.579965. bioRxiv. 2024. Update in: Clin Cancer Res. 2024 Sep 13;30(18):4029-4043. doi: 10.1158/1078-0432.CCR-24-0861 PMID: 38405716 Free PMC article. Updated. Preprint.
Local delivery of cell surface-targeted immunocytokines programs systemic antitumor immunity.
Santollani L, Maiorino L, Zhang YJ, Palmeri JR, Stinson JA, Duhamel LR, Qureshi K, Suggs JR, Porth OT, Pinney W 3rd, Msari RA, Walsh AA, Wittrup KD, Irvine DJ. Santollani L, et al. Among authors: wittrup kd. Nat Immunol. 2024 Oct;25(10):1820-1829. doi: 10.1038/s41590-024-01925-7. Epub 2024 Aug 7. Nat Immunol. 2024. PMID: 39112631 Free PMC article.
Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer.
Zagorulya M, Yim L, Morgan DM, Edwards A, Torres-Mejia E, Momin N, McCreery CV, Zamora IL, Horton BL, Fox JG, Wittrup KD, Love JC, Spranger S. Zagorulya M, et al. Among authors: wittrup kd. Immunity. 2023 Feb 14;56(2):386-405.e10. doi: 10.1016/j.immuni.2023.01.010. Epub 2023 Feb 2. Immunity. 2023. PMID: 36736322 Free PMC article.
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells.
Grzywa T, Mehta N, Cossette B, Romanov A, Paruzzo L, Ramasubramanian R, Cozzone A, Morgan D, Sukaj I, Bergaggio E, Tannir R, Kadauke S, Myers R, Yousefpour P, Ghilardi G, Schuster S, Neeser A, Frey N, Goncalves B, Zhang L, Abraham W, Suh H, Ruella M, Grupp S, Chiarle R, Wittrup KD, Ma L, Irvine DJ. Grzywa T, et al. Among authors: wittrup kd. bioRxiv [Preprint]. 2024 Oct 1:2024.04.16.589780. doi: 10.1101/2024.04.16.589780. bioRxiv. 2024. PMID: 38659938 Free PMC article. Preprint.
223 results