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The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner.
Joseph EW, Pratilas CA, Poulikakos PI, Tadi M, Wang W, Taylor BS, Halilovic E, Persaud Y, Xing F, Viale A, Tsai J, Chapman PB, Bollag G, Solit DB, Rosen N. Joseph EW, et al. Among authors: pratilas ca. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14903-8. doi: 10.1073/pnas.1008990107. Epub 2010 Jul 28. Proc Natl Acad Sci U S A. 2010. PMID: 20668238 Free PMC article.
Targeting oncogenic BRAF in human cancer.
Pratilas CA, Xing F, Solit DB. Pratilas CA, et al. Curr Top Microbiol Immunol. 2012;355:83-98. doi: 10.1007/82_2011_162. Curr Top Microbiol Immunol. 2012. PMID: 21818706 Free PMC article.
Ifosfamide dose-intensification for patients with metastatic Ewing sarcoma.
Magnan H, Goodbody CM, Riedel E, Pratilas CA, Wexler LH, Chou AJ. Magnan H, et al. Among authors: pratilas ca. Pediatr Blood Cancer. 2015 Apr;62(4):594-7. doi: 10.1002/pbc.25373. Epub 2015 Jan 28. Pediatr Blood Cancer. 2015. PMID: 25630954 Free PMC article. Clinical Trial.
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Okada T, Sinha S, Esposito I, Schiavon G, López-Lago MA, Su W, Pratilas CA, Abele C, Hernandez JM, Ohara M, Okada M, Viale A, Heguy A, Socci ND, Sapino A, Seshan VE, Long S, Inghirami G, Rosen N, Giancotti FG. Okada T, et al. Among authors: pratilas ca. Nat Cell Biol. 2015 Jan;17(1):81-94. doi: 10.1038/ncb3082. Epub 2014 Dec 22. Nat Cell Biol. 2015. PMID: 25531777 Free PMC article.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. Xing F, et al. Among authors: pratilas ca. Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4. Oncogene. 2012. PMID: 21725359 Free PMC article.
98 results