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Local senolysis in aged mice only partially replicates the benefits of systemic senolysis.
Farr JN, Saul D, Doolittle ML, Kaur J, Rowsey JL, Vos SJ, Froemming MN, Lagnado AB, Zhu Y, Weivoda M, Ikeno Y, Pignolo RJ, Niedernhofer LJ, Robbins PD, Jurk D, Passos JF, LeBrasseur NK, Tchkonia T, Kirkland JL, Monroe DG, Khosla S. Farr JN, et al. Among authors: froemming mn. J Clin Invest. 2023 Apr 17;133(8):e162519. doi: 10.1172/JCI162519. J Clin Invest. 2023. PMID: 36809340 Free PMC article.
Osteochondroprogenitor cells and neutrophils expressing p21 and senescence markers modulate fracture repair.
Saul D, Doolittle ML, Rowsey JL, Froemming MN, Kosinsky RL, Vos SJ, Ruan M, LeBrasseur N, Chandra A, Pignolo R, Passos JF, Farr JN, Monroe DG, Khosla S. Saul D, et al. Among authors: froemming mn. bioRxiv [Preprint]. 2024 Feb 7:2024.02.01.578420. doi: 10.1101/2024.02.01.578420. bioRxiv. 2024. Update in: J Clin Invest. 2024 May 16;134(12):e179834. doi: 10.1172/JCI179834 PMID: 38370844 Free PMC article. Updated. Preprint.