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A hyper-quiescent chromatin state formed during aging is reversed by regeneration.
Yang N, Occean JR, Melters DP, Shi C, Wang L, Stransky S, Doyle ME, Cui CY, Delannoy M, Fan J, Slama E, Egan JM, De S, Cunningham SC, de Cabo R, Sidoli S, Dalal Y, Sen P. Yang N, et al. Among authors: sen p. bioRxiv [Preprint]. 2023 Feb 15:2023.02.14.528512. doi: 10.1101/2023.02.14.528512. bioRxiv. 2023. Update in: Mol Cell. 2023 May 18;83(10):1659-1676.e11. doi: 10.1016/j.molcel.2023.04.005 PMID: 36824822 Free PMC article. Updated. Preprint.
The senescent cell epigenome.
Yang N, Sen P. Yang N, et al. Among authors: sen p. Aging (Albany NY). 2018 Nov 3;10(11):3590-3609. doi: 10.18632/aging.101617. Aging (Albany NY). 2018. PMID: 30391936 Free PMC article. Review.
The eroding chromatin landscape of aging stem cells.
Shi C, Wang L, Sen P. Shi C, et al. Among authors: sen p. Transl Med Aging. 2020;4:121-131. doi: 10.1016/j.tma.2020.08.002. Epub 2020 Aug 17. Transl Med Aging. 2020. PMID: 33024907 Free PMC article.
Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis.
Herman AB, Anerillas C, Harris SC, Munk R, Martindale JL, Yang X, Mazan-Mamczarz K, Zhang Y, Heckenbach IJ, Scheibye-Knudsen M, De S, Sen P, Abdelmohsen K, Gorospe M. Herman AB, et al. Among authors: sen p. Nucleic Acids Res. 2021 Jul 21;49(13):7389-7405. doi: 10.1093/nar/gkab538. Nucleic Acids Res. 2021. PMID: 34181735 Free PMC article.
A gradual path to mortality.
Yang N, Sen P. Yang N, et al. Among authors: sen p. Elife. 2022 Mar 18;11:e77749. doi: 10.7554/eLife.77749. Elife. 2022. PMID: 35302485 Free PMC article.
Single-Cell Analysis of the Transcriptome and Epigenome.
Mazan-Mamczarz K, Ha J, De S, Sen P. Mazan-Mamczarz K, et al. Among authors: sen p. Methods Mol Biol. 2022;2399:21-60. doi: 10.1007/978-1-0716-1831-8_3. Methods Mol Biol. 2022. PMID: 35604552 Free PMC article.
A dual-activity topoisomerase complex regulates mRNA translation and turnover.
Su S, Xue Y, Sharov A, Zhang Y, Lee SK, Martindale JL, Li W, Ku WL, Zhao K, De S, Shen W, Sen P, Gorospe M, Xu D, Wang W. Su S, et al. Among authors: sen p. Nucleic Acids Res. 2022 Jul 8;50(12):7013-7033. doi: 10.1093/nar/gkac538. Nucleic Acids Res. 2022. PMID: 35748872 Free PMC article.
1,547 results