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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR + CD8 + effector state and its deletion improves checkpoint blockade.
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. McClory SE, et al. bioRxiv [Preprint]. 2023 Feb 16:2023.02.16.528833. doi: 10.1101/2023.02.16.528833. bioRxiv. 2023. Update in: Cell Rep. 2023 Aug 29;42(8):112905. doi: 10.1016/j.celrep.2023.112905 PMID: 36824931 Free PMC article. Updated. Preprint.
FOXO1 is a master regulator of memory programming in CAR T cells.
Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, Daniel B, Lattin J, Markovska M, Mozarsky B, Arias-Umana J, Hapke R, Jung IY, Wang A, Xu P, Klysz D, Zuern G, Bashti M, Quinn PJ, Miao Z, Sandor K, Zhang W, Chen GM, Ryu F, Logun M, Hall J, Tan K, Grupp SA, McClory SE, Lareau CA, Fraietta JA, Sotillo E, Satpathy AT, Mackall CL, Weber EW. Doan AE, et al. Among authors: mcclory se. Nature. 2024 May;629(8010):211-218. doi: 10.1038/s41586-024-07300-8. Epub 2024 Apr 10. Nature. 2024. PMID: 38600391 Free PMC article.
Publisher Correction: FOXO1 is a master regulator of memory programming in CAR T cells.
Doan AE, Mueller KP, Chen AY, Rouin GT, Chen Y, Daniel B, Lattin J, Markovska M, Mozarsky B, Arias-Umana J, Hapke R, Jung IY, Wang A, Xu P, Klysz D, Zuern G, Bashti M, Quinn PJ, Miao Z, Sandor K, Zhang W, Chen GM, Ryu F, Logun M, Hall J, Tan K, Grupp SA, McClory SE, Lareau CA, Fraietta JA, Sotillo E, Satpathy AT, Mackall CL, Weber EW. Doan AE, et al. Among authors: mcclory se. Nature. 2024 May;629(8011):E11. doi: 10.1038/s41586-024-07450-9. Nature. 2024. PMID: 38654101 Free PMC article. No abstract available.
Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission.
Bai Z, Feng B, McClory SE, de Oliveira BC, Diorio C, Gregoire C, Tao B, Yang L, Zhao Z, Peng L, Sferruzza G, Zhou L, Zhou X, Kerr J, Baysoy A, Su G, Yang M, Camara PG, Chen S, Tang L, June CH, Melenhorst JJ, Grupp SA, Fan R. Bai Z, et al. Among authors: mcclory se. Nature. 2024 Oct;634(8034):702-711. doi: 10.1038/s41586-024-07762-w. Epub 2024 Sep 25. Nature. 2024. PMID: 39322664 Free PMC article.