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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR + CD8 + effector state and its deletion improves checkpoint blockade.
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. McClory SE, et al. Among authors: pear ws. bioRxiv [Preprint]. 2023 Feb 16:2023.02.16.528833. doi: 10.1101/2023.02.16.528833. bioRxiv. 2023. Update in: Cell Rep. 2023 Aug 29;42(8):112905. doi: 10.1016/j.celrep.2023.112905 PMID: 36824931 Free PMC article. Updated. Preprint.
Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naive B cells.
Gómez Atria D, Gaudette BT, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJ, Robertson TF, Burkhardt JK, Pear WS, Allman D, Maillard I. Gómez Atria D, et al. Among authors: pear ws. J Clin Invest. 2022 Jul 1;132(13):e158885. doi: 10.1172/JCI158885. J Clin Invest. 2022. PMID: 35579963 Free PMC article.
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation.
Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, Kopan R. Kobia FM, et al. Among authors: pear ws. PLoS Biol. 2020 Oct 5;18(10):e3000850. doi: 10.1371/journal.pbio.3000850. eCollection 2020 Oct. PLoS Biol. 2020. PMID: 33017398 Free PMC article.
TooManyCells identifies and visualizes relationships of single-cell clades.
Schwartz GW, Zhou Y, Petrovic J, Fasolino M, Xu L, Shaffer SM, Pear WS, Vahedi G, Faryabi RB. Schwartz GW, et al. Among authors: pear ws. Nat Methods. 2020 Apr;17(4):405-413. doi: 10.1038/s41592-020-0748-5. Epub 2020 Mar 2. Nat Methods. 2020. PMID: 32123397 Free PMC article.
155 results