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Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease.
Jones KM, Mangin EN, Reynolds CL, Villanueva LE, Cruz JV, Versteeg L, Keegan B, Kendricks A, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ. Jones KM, et al. Among authors: gusovsky f. Front Cell Infect Microbiol. 2023 Feb 9;13:1106315. doi: 10.3389/fcimb.2023.1106315. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36844399 Free PMC article.
Dirofilariasis mouse models for heartworm preclinical research.
Marriott AE, Dagley JL, Hegde S, Steven A, Fricks C, DiCosty U, Mansour A, Campbell EJ, Wilson CM, Gusovsky F, Ward SA, Hong WD, O'Neill P, Moorhead A, McCall S, McCall JW, Taylor MJ, Turner JD. Marriott AE, et al. Among authors: gusovsky f. Front Microbiol. 2023 Jun 22;14:1208301. doi: 10.3389/fmicb.2023.1208301. eCollection 2023. Front Microbiol. 2023. PMID: 37426014 Free PMC article.
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.
Hegde S, Marriott AE, Pionnier N, Steven A, Bulman C, Gunderson E, Vogel I, Koschel M, Ehrens A, Lustigman S, Voronin D, Tricoche N, Hoerauf A, Hübner MP, Sakanari J, Aljayyoussi G, Gusovsky F, Dagley J, Hong DW, O'Neill P, Ward SA, Taylor MJ, Turner JD. Hegde S, et al. Among authors: gusovsky f. Front Microbiol. 2024 Feb 1;15:1346068. doi: 10.3389/fmicb.2024.1346068. eCollection 2024. Front Microbiol. 2024. PMID: 38362501 Free PMC article.
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti-Wolbachia Candidate Macrofilaricide.
Devereux G, Bula M, Tripp K, Fitzgerald R, Eraut N, Alam MS, Moriyama T, Shinkyo R, Walker L, Wang D, Gusovsky F, van der Velde J, Turner JD, Hong WD, O'Neill PM, Taylor MJ, Ward SA. Devereux G, et al. Among authors: gusovsky f. Clin Pharmacol Drug Dev. 2024 Sep;13(9):1071-1081. doi: 10.1002/cpdd.1441. Epub 2024 Jun 24. Clin Pharmacol Drug Dev. 2024. PMID: 38924387 Clinical Trial.
The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection.
Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. Nguyen DM, et al. Among authors: gusovsky f. bioRxiv [Preprint]. 2023 Jul 12:2023.07.11.548497. doi: 10.1101/2023.07.11.548497. bioRxiv. 2023. Update in: PLoS Negl Trop Dis. 2023 Nov 21;17(11):e0011519. doi: 10.1371/journal.pntd.0011519 PMID: 37503013 Free PMC article. Updated. Preprint.
Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease.
Liu Z, Ulrich R, Kendricks AL, Wheeler K, Leão AC, Pollet J, Bottazzi ME, Hotez P, Gusovsky F, Jones KM, McCall LI. Liu Z, et al. Among authors: gusovsky f. Res Sq [Preprint]. 2023 Jan 20:rs.3.rs-2497474. doi: 10.21203/rs.3.rs-2497474/v1. Res Sq. 2023. Update in: Nat Commun. 2023 Oct 25;14(1):6769. doi: 10.1038/s41467-023-42247-w PMID: 36711878 Free PMC article. Updated. Preprint.
Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by Trypanosoma cruzi in chronically-infected BALB/c mice.
Dzul-Huchim VM, Ramirez-Sierra MJ, Martinez-Vega PP, Rosado-Vallado ME, Arana-Argaez VE, Ortega-Lopez J, Gusovsky F, Dumonteil E, Cruz-Chan JV, Hotez P, Bottazzi ME, Villanueva-Lizama LE. Dzul-Huchim VM, et al. Among authors: gusovsky f. PLoS Negl Trop Dis. 2022 Sep 12;16(9):e0010258. doi: 10.1371/journal.pntd.0010258. eCollection 2022 Sep. PLoS Negl Trop Dis. 2022. PMID: 36095001 Free PMC article.
Combining SJ733, an oral ATP4 inhibitor of Plasmodium falciparum, with the pharmacokinetic enhancer cobicistat: An innovative approach in antimalarial drug development.
Gaur AH, Panetta JC, Smith AM, Dallas RH, Freeman BB 3rd, Stewart TB, Tang L, John E, Branum KC, Patel ND, Ost S, Heine RN, Richardson JL, Hammill JT, Bebrevska L, Gusovsky F, Maki N, Yanagi T, Flynn PM, McCarthy JS, Chalon S, Guy RK. Gaur AH, et al. Among authors: gusovsky f. EBioMedicine. 2022 Jun;80:104065. doi: 10.1016/j.ebiom.2022.104065. Epub 2022 May 19. EBioMedicine. 2022. PMID: 35598441 Free PMC article. Clinical Trial.
The Tuberculosis Drug Accelerator at year 10: what have we learned?
Aldridge BB, Barros-Aguirre D, Barry CE 3rd, Bates RH, Berthel SJ, Boshoff HI, Chibale K, Chu XJ, Cooper CB, Dartois V, Duncan K, Fotouhi N, Gusovsky F, Hipskind PA, Kempf DJ, Lelièvre J, Lenaerts AJ, McNamara CW, Mizrahi V, Nathan C, Olsen DB, Parish T, Petrassi HM, Pym A, Rhee KY, Robertson GT, Rock JM, Rubin EJ, Russell B, Russell DG, Sacchettini JC, Schnappinger D, Schrimpf M, Upton AM, Warner P, Wyatt PG, Yuan Y. Aldridge BB, et al. Among authors: gusovsky f. Nat Med. 2021 Aug;27(8):1333-1337. doi: 10.1038/s41591-021-01442-2. Nat Med. 2021. PMID: 34226736 Free PMC article.
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