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Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors.
Harrison D, Boutard N, Brzozka K, Bugaj M, Chmielewski S, Cierpich A, Doedens JR, Fabritius CRY, Gabel CA, Galezowski M, Kowalczyk P, Levenets O, Mroczkowska M, Palica K, Porter RA, Schultz D, Sowinska M, Topolnicki G, Urbanski P, Woyciechowski J, Watt AP. Harrison D, et al. Among authors: chmielewski s. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127560. doi: 10.1016/j.bmcl.2020.127560. Epub 2020 Sep 18. Bioorg Med Chem Lett. 2020. PMID: 32956781
STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury.
Kemmner S, Bachmann Q, Steiger S, Lorenz G, Honarpisheh M, Foresto-Neto O, Wang S, Carbajo-Lozoya J, Alt V, Schulte C, Chmielewski S, Bluyssen HAR, Heemann U, Baumann M, Lech M, Schmaderer C. Kemmner S, et al. Among authors: chmielewski s. Am J Physiol Renal Physiol. 2019 Feb 1;316(2):F277-F291. doi: 10.1152/ajprenal.00004.2018. Epub 2018 Nov 7. Am J Physiol Renal Physiol. 2019. PMID: 30403164 Free article.
Measuring clinically relevant endpoints in a serum-free, three-dimensional, primary cell culture system of human osteoarthritic articular chondrocytes.
Bundens G, Buckley A, Milton L, Behling K, Chmielewski S, Cho E, Lozano-Torres X, Selim A, Lackman R, George-Weinstein M, Miller L, D'Angelo M. Bundens G, et al. Among authors: chmielewski s. Exp Cell Res. 2017 Aug 15;357(2):310-319. doi: 10.1016/j.yexcr.2017.06.001. Epub 2017 Jun 2. Exp Cell Res. 2017. PMID: 28583763
32 results