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Page 1
Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions.
Soriano-Baguet L, Grusdat M, Kurniawan H, Benzarti M, Binsfeld C, Ewen A, Longworth J, Bonetti L, Guerra L, Franchina DG, Kobayashi T, Horkova V, Verschueren C, Helgueta S, Gérard D, More TH, Henne A, Dostert C, Farinelle S, Lesur A, Gérardy JJ, Jäger C, Mittelbronn M, Sinkkonen L, Hiller K, Meiser J, Brenner D. Soriano-Baguet L, et al. Among authors: verschueren c. Cell Rep. 2023 Mar 28;42(3):112153. doi: 10.1016/j.celrep.2023.112153. Epub 2023 Feb 26. Cell Rep. 2023. PMID: 36848289 Free article.
Mesaconate is synthesized from itaconate and exerts immunomodulatory effects in macrophages.
He W, Henne A, Lauterbach M, Geißmar E, Nikolka F, Kho C, Heinz A, Dostert C, Grusdat M, Cordes T, Härm J, Goldmann O, Ewen A, Verschueren C, Blay-Cadanet J, Geffers R, Garritsen H, Kneiling M, Holm CK, Metallo CM, Medina E, Abdullah Z, Latz E, Brenner D, Hiller K. He W, et al. Among authors: verschueren c. Nat Metab. 2022 May;4(5):524-533. doi: 10.1038/s42255-022-00565-1. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655024 Free PMC article.
Itaconate controls its own synthesis via feedback-inhibition of reverse TCA cycle activity at IDH2.
Heinz A, Nonnenmacher Y, Henne A, Khalil MA, Bejkollari K, Dostert C, Hosseini S, Goldmann O, He W, Palorini R, Verschueren C, Korte M, Chiaradonna F, Medina E, Brenner D, Hiller K. Heinz A, et al. Among authors: verschueren c. Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166530. doi: 10.1016/j.bbadis.2022.166530. Epub 2022 Aug 28. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 36038039 Free article.
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Grusdat M, Spath S, Koncina E, Ewen A, Binsfeld C, Verschueren C, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Among authors: verschueren c. bioRxiv [Preprint]. 2023 Jul 7:2023.07.06.547932. doi: 10.1101/2023.07.06.547932. bioRxiv. 2023. Update in: Cell Metab. 2024 Aug 6;36(8):1726-1744.e10. doi: 10.1016/j.cmet.2024.06.010 PMID: 37489135 Free PMC article. Updated. Preprint.
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation.
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan YT, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. Bonetti L, et al. Among authors: verschueren c. Cell Metab. 2024 Aug 6;36(8):1726-1744.e10. doi: 10.1016/j.cmet.2024.06.010. Epub 2024 Jul 9. Cell Metab. 2024. PMID: 38986617 Free article.
Altered infective competence of the human gut microbiome in COVID-19.
de Nies L, Galata V, Martin-Gallausiaux C, Despotovic M, Busi SB, Snoeck CJ, Delacour L, Budagavi DP, Laczny CC, Habier J, Lupu PC, Halder R, Fritz JV, Marques T, Sandt E, O'Sullivan MP, Ghosh S, Satagopam V; CON-VINCE Consortium; Krüger R, Fagherazzi G, Ollert M, Hefeng FQ, May P, Wilmes P. de Nies L, et al. Microbiome. 2023 Mar 9;11(1):46. doi: 10.1186/s40168-023-01472-7. Microbiome. 2023. PMID: 36894986 Free PMC article.
Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE).
Tsurkalenko O, Bulaev D, O'Sullivan MP, Snoeck C, Ghosh S, Kolodkin A, Rommes B, Gawron P, Moreno CV, Gomes CPC, Kaysen A, Ohnmacht J, Schröder VE, Pavelka L, Meyers GR, Pauly L, Pauly C, Hanff AM, Meyrath M, Leist A, Sandt E, Aguayo GA, Perquin M, Gantenbein M, Abdelrahman T, Klucken J, Satagopam V, Hilger C, Turner J, Vaillant M, Fritz JV, Ollert M, Krüger R; CON-VINCE consortium and the ORCHESTRA working group. Tsurkalenko O, et al. BMC Infect Dis. 2024 Feb 9;24(1):179. doi: 10.1186/s12879-024-09055-z. BMC Infect Dis. 2024. PMID: 38336649 Free PMC article.
39 results