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Sterol regulatory element-binding protein 2 maintains glioblastoma stem cells by keeping the balance between cholesterol biosynthesis and uptake.
Gu D, Zhou F, You H, Gao J, Kang T, Dixit D, Wu Q, Yang K, Ci S, Shan D, Fan X, Yuan W, Zhang Q, Lu C, Li D, Zhao N, Shi Z, Gao W, Lin F, Man J, Wang Q, Qian X, Mack SC, Tao W, Agnihotri S, Zhang N, You Y, Rich JN, Zhang J, Wang X. Gu D, et al. Among authors: agnihotri s. Neuro Oncol. 2023 Sep 5;25(9):1578-1591. doi: 10.1093/neuonc/noad060. Neuro Oncol. 2023. PMID: 36934350 Free PMC article.
Sorting nexin 10 sustains PDGF receptor signaling in glioblastoma stem cells via endosomal protein sorting.
Gimple RC, Zhang G, Wang S, Huang T, Lee J, Taori S, Lv D, Dixit D, Halbert ME, Morton AR, Kidwell RL, Dong Z, Prager BC, Kim LJ, Qiu Z, Zhao L, Xie Q, Wu Q, Agnihotri S, Rich JN. Gimple RC, et al. Among authors: agnihotri s. JCI Insight. 2023 Mar 22;8(6):e158077. doi: 10.1172/jci.insight.158077. JCI Insight. 2023. PMID: 36795488 Free PMC article.
Threonine fuels glioblastoma through YRDC-mediated codon-biased translational reprogramming.
Wu X, Yuan H, Wu Q, Gao Y, Duan T, Yang K, Huang T, Wang S, Yuan F, Lee D, Taori S, Plute T, Heissel S, Alwaseem H, Isay-Del Viscio M, Molina H, Agnihotri S, Hsu DJ, Zhang N, Rich JN. Wu X, et al. Among authors: agnihotri s. Nat Cancer. 2024 Jul;5(7):1024-1044. doi: 10.1038/s43018-024-00748-7. Epub 2024 Mar 22. Nat Cancer. 2024. PMID: 38519786
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2.
Lv D, Dixit D, Cruz AF, Kim LJY, Duan L, Xu X, Wu Q, Zhong C, Lu C, Gersey ZC, Gimple RC, Xie Q, Yang K, Liu X, Fang X, Wu X, Kidwell RL, Wang X, Bao S, He HH, Locasale JW, Agnihotri S, Rich JN. Lv D, et al. Among authors: agnihotri s. Cell Metab. 2024 Nov 5;36(11):2419-2436.e8. doi: 10.1016/j.cmet.2024.09.014. Epub 2024 Oct 24. Cell Metab. 2024. PMID: 39454581
Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.
Jane EP, Reslink MC, Gatesman TA, Halbert ME, Miller TA, Golbourn BJ, Casillo SM, Mullett SJ, Wendell SG, Obodo U, Mohanakrishnan D, Dange R, Michealraj A, Brenner C, Agnihotri S, Premkumar DR, Pollack IF. Jane EP, et al. Among authors: agnihotri s. Mol Oncol. 2023 Sep;17(9):1821-1843. doi: 10.1002/1878-0261.13427. Epub 2023 May 12. Mol Oncol. 2023. PMID: 37014128 Free PMC article.
Circulating tumor DNA - A potential aid in the management of chordomas.
Frederico SC, Darling C, Zhang X, Huq S, Agnihotri S, Gardner PA, Snyderman CH, Wang EW, Zenonos GA. Frederico SC, et al. Among authors: agnihotri s. Front Oncol. 2022 Oct 20;12:1016385. doi: 10.3389/fonc.2022.1016385. eCollection 2022. Front Oncol. 2022. PMID: 36338734 Free PMC article. Review.
Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma.
Mbah NE, Myers AL, Sajjakulnukit P, Chung C, Thompson JK, Hong HS, Giza H, Dang D, Nwosu ZC, Shan M, Sweha SR, Maydan DD, Chen B, Zhang L, Magnuson B, Zhu Z, Radyk M, Lavoie B, Yadav VN, Koo I, Patterson AD, Wahl DR, Franchi L, Agnihotri S, Koschmann CJ, Venneti S, Lyssiotis CA. Mbah NE, et al. Among authors: agnihotri s. Nat Commun. 2024 Oct 17;15(1):8983. doi: 10.1038/s41467-024-52973-4. Nat Commun. 2024. PMID: 39419964 Free PMC article.
Assessment of anti-CD69 antibody therapy alone or in combination with anti-PD-1 in murine GBM.
Nisnboym M, Sneiderman CT, Jaswal AP, Xiong Z, Vincze SR, Sever RE, Zou H, Frederico SC, Agnihotri S, Hu B, Drappatz J, Pollack IF, Kohanbash G, Raphael I. Nisnboym M, et al. Among authors: agnihotri s. Expert Rev Clin Immunol. 2024 Oct 14:1-9. doi: 10.1080/1744666X.2024.2412770. Online ahead of print. Expert Rev Clin Immunol. 2024. PMID: 39402706
The landscape of tumor cell states and spatial organization in H3-K27M mutant diffuse midline glioma across age and location.
Liu I, Jiang L, Samuelsson ER, Marco Salas S, Beck A, Hack OA, Jeong D, Shaw ML, Englinger B, LaBelle J, Mire HM, Madlener S, Mayr L, Quezada MA, Trissal M, Panditharatna E, Ernst KJ, Vogelzang J, Gatesman TA, Halbert ME, Palova H, Pokorna P, Sterba J, Slaby O, Geyeregger R, Diaz A, Findlay IJ, Dun MD, Resnick A, Suvà ML, Jones DTW, Agnihotri S, Svedlund J, Koschmann C, Haberler C, Czech T, Slavc I, Cotter JA, Ligon KL, Alexandrescu S, Yung WKA, Arrillaga-Romany I, Gojo J, Monje M, Nilsson M, Filbin MG. Liu I, et al. Among authors: agnihotri s. Nat Genet. 2022 Dec;54(12):1881-1894. doi: 10.1038/s41588-022-01236-3. Epub 2022 Dec 5. Nat Genet. 2022. PMID: 36471067 Free PMC article.
320 results