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Reversal of deficits in aged skeletal muscle during disuse and recovery in response to treatment with a secrotome product derived from partially differentiated human pluripotent stem cells.
Fix DK, Mahmassani ZS, Petrocelli JJ, de Hart NMMP, Ferrara PJ, Painter JS, Nistor G, Lane TE, Keirstead HS, Drummond MJ. Fix DK, et al. Among authors: de hart nmmp. Geroscience. 2021 Dec;43(6):2635-2652. doi: 10.1007/s11357-021-00423-0. Epub 2021 Aug 24. Geroscience. 2021. PMID: 34427856 Free PMC article.
Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial.
McKenzie AI, Mahmassani ZS, Petrocelli JJ, de Hart NMMP, Fix DK, Ferrara PJ, LaStayo PC, Marcus RL, Rondina MT, Summers SA, Johnson JM, Trinity JD, Funai K, Drummond MJ. McKenzie AI, et al. Among authors: de hart nmmp. Exp Gerontol. 2022 Jun 15;163:111804. doi: 10.1016/j.exger.2022.111804. Epub 2022 Apr 9. Exp Gerontol. 2022. PMID: 35405248 Free PMC article. Clinical Trial.
Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: a pilot study.
Reidy PT, Smith AD, Jevnikar BE, Doctor AK, Williams RW, Kachulkin AA, Monnig JM, Fix DK, Petrocelli JJ, Mahmassani ZS, McKenzie AI, de Hart NMMP, Drummond MJ. Reidy PT, et al. Among authors: de hart nmmp. J Appl Physiol (1985). 2023 Apr 1;134(4):787-798. doi: 10.1152/japplphysiol.00681.2022. Epub 2023 Feb 9. J Appl Physiol (1985). 2023. PMID: 36759163 Free PMC article.
Global deletion of CCL2 has adverse impacts on recovery of skeletal muscle fiber size and function and is muscle specific.
Ferrara PJ, Reidy PT, Petrocelli JJ, Yee EM, Fix DK, Mahmassani ZS, Montgomery JA, McKenzie AI, de Hart NMMP, Drummond MJ. Ferrara PJ, et al. Among authors: de hart nmmp. J Appl Physiol (1985). 2023 Apr 1;134(4):923-932. doi: 10.1152/japplphysiol.00444.2022. Epub 2023 Mar 2. J Appl Physiol (1985). 2023. PMID: 36861669 Free PMC article.
Disuse-induced muscle fibrosis, cellular senescence, and senescence-associated secretory phenotype in older adults are alleviated during re-ambulation with metformin pre-treatment.
Petrocelli JJ, McKenzie AI, de Hart NMMP, Reidy PT, Mahmassani ZS, Keeble AR, Kaput KL, Wahl MP, Rondina MT, Marcus RL, Welt CK, Holland WL, Funai K, Fry CS, Drummond MJ. Petrocelli JJ, et al. Among authors: de hart nmmp. Aging Cell. 2023 Nov;22(11):e13936. doi: 10.1111/acel.13936. Epub 2023 Jul 24. Aging Cell. 2023. PMID: 37486024 Free PMC article. Clinical Trial.
Stem cell secretome treatment improves whole-body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice.
Fennel ZJ, Bourrant PE, Kurian AS, Petrocelli JJ, de Hart NMMP, Yee EM, Boudina S, Keirstead HS, Nistor G, Greilach SA, Berchtold NC, Lane TE, Drummond MJ. Fennel ZJ, et al. Among authors: de hart nmmp. Aging Cell. 2024 Jun;23(6):e14144. doi: 10.1111/acel.14144. Epub 2024 Mar 18. Aging Cell. 2024. PMID: 38500398 Free PMC article.
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