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Page 1
Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature.
Sievers P, Sill M, Schrimpf D, Abdullaev Z, Donson AM, Lake JA, Friedel D, Scheie D, Tynninen O, Rauramaa T, Vepsäläinen KL, Samuel D, Chapman R, Grundy RG, Pajtler KW, Tauziède-Espariat A, Métais A, Varlet P, Snuderl M, Jacques TS, Aldape K, Reuss DE, Korshunov A, Wick W, Pfister SM, von Deimling A, Sahm F, Jones DTW. Sievers P, et al. Among authors: friedel d. NPJ Precis Oncol. 2023 Mar 24;7(1):30. doi: 10.1038/s41698-023-00372-1. NPJ Precis Oncol. 2023. PMID: 36964296 Free PMC article.
Tryptophan metabolism is inversely regulated in the tumor and blood of patients with glioblastoma.
Panitz V, Končarević S, Sadik A, Friedel D, Bausbacher T, Trump S, Farztdinov V, Schulz S, Sievers P, Schmidt S, Jürgenson I, Jung S, Kuhn K, Pflüger I, Sharma S, Wick A, Pfänder P, Selzer S, Vollmuth P, Sahm F, von Deimling A, Heiland I, Hopf C, Schulz-Knappe P, Pike I, Platten M, Wick W, Opitz CA. Panitz V, et al. Among authors: friedel d. Theranostics. 2021 Sep 3;11(19):9217-9233. doi: 10.7150/thno.60679. eCollection 2021. Theranostics. 2021. PMID: 34646367 Free PMC article.
Oligosarcomas, IDH-mutant are distinct and aggressive.
Suwala AK, Felix M, Friedel D, Stichel D, Schrimpf D, Hinz F, Hewer E, Schweizer L, Dohmen H, Pohl U, Staszewski O, Korshunov A, Stein M, Wongsurawat T, Cheunsuacchon P, Sathornsumetee S, Koelsche C, Turner C, Le Rhun E, Mühlebner A, Schucht P, Özduman K, Ono T, Shimizu H, Prinz M, Acker T, Herold-Mende C, Kessler T, Wick W, Capper D, Wesseling P, Sahm F, von Deimling A, Hartmann C, Reuss DE. Suwala AK, et al. Among authors: friedel d. Acta Neuropathol. 2022 Feb;143(2):263-281. doi: 10.1007/s00401-021-02395-z. Epub 2021 Dec 30. Acta Neuropathol. 2022. PMID: 34967922 Free PMC article.
HIP1R and vimentin immunohistochemistry predict 1p/19q status in IDH-mutant glioma.
Felix M, Friedel D, Jayavelu AK, Filipski K, Reinhardt A, Warnken U, Stichel D, Schrimpf D, Korshunov A, Wang Y, Kessler T, Etminan N, Unterberg A, Herold-Mende C, Heikaus L, Sahm F, Wick W, Harter PN, von Deimling A, Reuss DE. Felix M, et al. Among authors: friedel d. Neuro Oncol. 2022 Dec 1;24(12):2121-2132. doi: 10.1093/neuonc/noac111. Neuro Oncol. 2022. PMID: 35511748 Free PMC article.
Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases.
Sievers P, Sill M, Schrimpf D, Friedel D, Sturm D, Gardberg M, Kurian KM, Krskova L, Vicha A, Schaller T, Hagel C, Abdullaev Z, Aldape K, Jacques TS, Korshunov A, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F. Sievers P, et al. Among authors: friedel d. Acta Neuropathol. 2022 Nov;144(5):1049-1052. doi: 10.1007/s00401-022-02492-7. Epub 2022 Sep 7. Acta Neuropathol. 2022. PMID: 36070143 Free PMC article. No abstract available.
Glioneuronal tumor with ATRX alteration, kinase fusion and anaplastic features (GTAKA): a molecularly distinct brain tumor type with recurrent NTRK gene fusions.
Bogumil H, Sill M, Schrimpf D, Ismer B, Blume C, Rahmanzade R, Hinz F, Cherkezov A, Banan R, Friedel D, Reuss DE, Selt F, Ecker J, Milde T, Pajtler KW, Schittenhelm J, Hench J, Frank S, Boldt HB, Kristensen BW, Scheie D, Melchior LC, Olesen V, Sehested A, Boué DR, Abdullaev Z, Satgunaseelan L, Kurth I, Seidlitz A, White CL, Ng HK, Shi ZF, Haberler C, Deckert M, Timmer M, Goldbrunner R, Tauziède-Espariat A, Varlet P, Brandner S, Alexandrescu S, Snuderl M, Aldape K, Korshunov A, Witt O, Herold-Mende C, Unterberg A, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F, Sievers P. Bogumil H, et al. Among authors: friedel d. Acta Neuropathol. 2023 May;145(5):667-680. doi: 10.1007/s00401-023-02558-0. Epub 2023 Mar 18. Acta Neuropathol. 2023. PMID: 36933012 Free PMC article.
Integrated genetic analyses of immunodeficiency-associated Epstein-Barr virus- (EBV) positive primary CNS lymphomas.
Kaulen LD, Denisova E, Hinz F, Hai L, Friedel D, Henegariu O, Hoffmann DC, Ito J, Kourtesakis A, Lehnert P, Doubrovinskaia S, Karschnia P, von Baumgarten L, Kessler T, Baehring JM, Brors B, Sahm F, Wick W. Kaulen LD, et al. Among authors: friedel d. Acta Neuropathol. 2023 Sep;146(3):499-514. doi: 10.1007/s00401-023-02613-w. Epub 2023 Jul 26. Acta Neuropathol. 2023. PMID: 37495858 Free PMC article.
Genetical and epigenetical profiling identifies two subgroups of pineal parenchymal tumors of intermediate differentiation (PPTID) with distinct molecular, histological and clinical characteristics.
Rahmanzade R, Pfaff E, Banan R, Sievers P, Suwala AK, Hinz F, Bogumil H, Cherkezov A, Kaan AF, Schrimpf D, Friedel D, Göbel K, Keller F, Saenz-Sardà X, Lossos A, Sill M, Witt O, Sakowitz OW, Korshunov A, Reuss DE, Etminan N, Unterberg A, Ratliff M, Herold-Mende C, Wick W, Pfister SM, von Deimling A, Jones DTW, Sahm F. Rahmanzade R, et al. Among authors: friedel d. Acta Neuropathol. 2023 Dec;146(6):853-856. doi: 10.1007/s00401-023-02638-1. Epub 2023 Sep 30. Acta Neuropathol. 2023. PMID: 37776353 Free PMC article. No abstract available.
Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.
Kocher D, Cao L, Guiho R, Langhammer M, Lai YL, Becker P, Hamdi H, Friedel D, Selt F, Vonhören D, Zaman J, Valinciute G, Herter S, Picard D, Rettenmeier J, Maass KK, Pajtler KW, Remke M, von Deimling A, Pusch S, Pfister SM, Oehme I, Jones DTW, Halbach S, Brummer T, Martinez-Barbera JP, Witt O, Milde T, Sigaud R. Kocher D, et al. Among authors: friedel d. J Neurooncol. 2024 Jun;168(2):317-332. doi: 10.1007/s11060-024-04672-9. Epub 2024 Apr 17. J Neurooncol. 2024. PMID: 38630384 Free PMC article.
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