Chen H - Search Results

1

Tumor Cell-Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer.

Chen H, Cresswell GM, Libring S, Ayers MG, Miao J, Zhang ZY, Solorio L, Ratliff TL, Wendt MK. Chen H, et al. Cancer Res Commun. 2022 Oct 3;2(10):1104-1118. doi: 10.1158/2767-9764.CRC-22-0117. eCollection 2022 Oct. Cancer Res Commun. 2022. PMID: 36969745 Free PMC article.

2

Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer.

Shinde A, Wilmanski T, Chen H, Teegarden D, Wendt MK. Shinde A, et al. Among authors: chen h. Breast Cancer Res. 2018 Jul 13;20(1):76. doi: 10.1186/s13058-018-1008-9. Breast Cancer Res. 2018. PMID: 30005601 Free PMC article.

3

Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library.

Kim D, Sun Y, Xie D, Denton KE, Chen H, Lin H, Wendt MK, Post CB, Krusemark CJ. Kim D, et al. Among authors: chen h. Molecules. 2019 Jul 30;24(15):2764. doi: 10.3390/molecules24152764. Molecules. 2019. PMID: 31366048 Free PMC article.

4

Ubiquitin C-Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine-Based Inhibitor.

Krabill AD, Chen H, Hussain S, Feng C, Abdullah A, Das C, Aryal UK, Post CB, Wendt MK, Galardy PJ, Flaherty DP. Krabill AD, et al. Among authors: chen h. Chembiochem. 2020 Mar 2;21(5):712-722. doi: 10.1002/cbic.201900434. Epub 2019 Nov 7. Chembiochem. 2020. PMID: 31449350 Free PMC article.

5

SHP2 is a multifunctional therapeutic target in drug resistant metastatic breast cancer.

Chen H, Libring S, Ruddraraju KV, Miao J, Solorio L, Zhang ZY, Wendt MK. Chen H, et al. Oncogene. 2020 Dec;39(49):7166-7180. doi: 10.1038/s41388-020-01488-5. Epub 2020 Oct 8. Oncogene. 2020. PMID: 33033382 Free PMC article.

6

Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy.

Akhand SS, Chen H, Purdy SC, Liu Z, Anderson JC, Willey CD, Wendt MK. Akhand SS, et al. Among authors: chen h. NPJ Breast Cancer. 2021 Jan 21;7(1):5. doi: 10.1038/s41523-020-00213-5. NPJ Breast Cancer. 2021. PMID: 33479246 Free PMC article.

7

Optimization and Anti-Cancer Properties of Fluoromethylketones as Covalent Inhibitors for Ubiquitin C-Terminal Hydrolase L1.

Krabill AD, Chen H, Hussain S, Hewitt CS, Imhoff RD, Muli CS, Das C, Galardy PJ, Wendt MK, Flaherty DP. Krabill AD, et al. Among authors: chen h. Molecules. 2021 Feb 25;26(5):1227. doi: 10.3390/molecules26051227. Molecules. 2021. PMID: 33668938 Free PMC article.

8

Transglutaminase-2 mediates acquisition of neratinib resistance in metastatic breast cancer.

Shinde A, Kulkoyluoglu Cotul E, Chen H, Smith A, Libring S, Solorio L, Wendt MK. Shinde A, et al. Among authors: chen h. Mol Biomed. 2022 Jun 22;3(1):19. doi: 10.1186/s43556-022-00079-y. Mol Biomed. 2022. PMID: 35729402 Free PMC article.

9

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.

Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington ND, Babon JJ, Kershaw NJ, Zhang ZY, Baell JB, Wiede F, Tiganis T. Liang S, et al. Among authors: chen h. Nat Commun. 2023 Jul 27;14(1):4524. doi: 10.1038/s41467-023-40170-8. Nat Commun. 2023. PMID: 37500611 Free PMC article.

10

Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1.

Imhoff RD, Patel R, Safdar MH, Jones HBL, Pinto-Fernandez A, Vendrell I, Chen H, Muli CS, Krabill AD, Kessler BM, Wendt MK, Das C, Flaherty DP. Imhoff RD, et al. Among authors: chen h. J Med Chem. 2024 Mar 28;67(6):4496-4524. doi: 10.1021/acs.jmedchem.3c01661. Epub 2024 Mar 15. J Med Chem. 2024. PMID: 38488146

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