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Systemic inhibition of PTPN22 augments anticancer immunity.
Ho WJ, Croessmann S, Lin J, Phyo ZH, Charmsaz S, Danilova L, Mohan AA, Gross NE, Chen F, Dong J, Aggarwal D, Bai Y, Wang J, He J, Leatherman JM, Yarchoan M, Armstrong TD, Zaidi N, Fertig EJ, Denny JC, Park BH, Zhang ZY, Jaffee EM. Ho WJ, et al. Among authors: dong j. J Clin Invest. 2021 Jul 20;131(17):e146950. doi: 10.1172/JCI146950. Online ahead of print. J Clin Invest. 2021. PMID: 34283806 Free PMC article.
A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
Liang S, Tran E, Du X, Dong J, Sudholz H, Chen H, Qu Z, Huntington N, Babon J, Kershaw N, Zhang ZY, Baell J, Wiede F, Tiganis T. Liang S, et al. Among authors: dong j. bioRxiv [Preprint]. 2023 Jun 28:2023.06.16.545220. doi: 10.1101/2023.06.16.545220. bioRxiv. 2023. Update in: Nat Commun. 2023 Jul 27;14(1):4524. doi: 10.1038/s41467-023-40170-8. PMID: 37397992 Free PMC article. Updated. Preprint.
Discovery of a SHP2 Degrader with In Vivo Anti-Tumor Activity.
Miao J, Bai Y, Miao Y, Qu Z, Dong J, Zhang RY, Aggarwal D, Jassim BA, Nguyen Q, Zhang ZY. Miao J, et al. Among authors: dong j. Molecules. 2023 Oct 6;28(19):6947. doi: 10.3390/molecules28196947. Molecules. 2023. PMID: 37836790 Free PMC article.
Discovery of a selective TC-PTP degrader for cancer immunotherapy.
Miao J, Dong J, Miao Y, Bai Y, Qu Z, Jassim BA, Huang B, Nguyen Q, Ma Y, Murray AA, Li J, Low PS, Zhang ZY. Miao J, et al. Among authors: dong j. Chem Sci. 2023 Oct 24;14(44):12606-12614. doi: 10.1039/d3sc04541b. eCollection 2023 Nov 15. Chem Sci. 2023. PMID: 38020389 Free PMC article.
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.
Jesudason CD, Mason ER, Chu S, Oblak AL, Javens-Wolfe J, Moussaif M, Durst G, Hipskind P, Beck DE, Dong J, Amarasinghe O, Zhang ZY, Hamdani AK, Singhal K, Mesecar AD, Souza S, Jacobson M, Salvo JD, Soni DM, Kandasamy M, Masters AR, Quinney SK, Doolen S, Huhe H, Rizzo SJS, Lamb BT, Palkowitz AD, Richardson TI. Jesudason CD, et al. Among authors: dong j. Alzheimers Dement (N Y). 2023 Nov 17;9(4):e12429. doi: 10.1002/trc2.12429. eCollection 2023 Oct-Dec. Alzheimers Dement (N Y). 2023. PMID: 38023622 Free PMC article.
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