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Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial.
Hong DS, Postow M, Chmielowski B, Sullivan R, Patnaik A, Cohen EEW, Shapiro G, Steuer C, Gutierrez M, Yeckes-Rodin H, Ilaria R, O'Connell B, Peng J, Peng G, Zizlsperger N, Tolcher A, Wolchok JD. Hong DS, et al. Clin Cancer Res. 2023 Jun 13;29(12):2210-2219. doi: 10.1158/1078-0432.CCR-22-3313. Clin Cancer Res. 2023. PMID: 37000164 Free PMC article. Clinical Trial.
Eganelisib combined with immune checkpoint inhibitor therapy and chemotherapy in frontline metastatic triple-negative breast cancer triggers macrophage reprogramming, immune activation and extracellular matrix reorganization in the tumor microenvironment.
O'Connell BC, Hubbard C, Zizlsperger N, Fitzgerald D, Kutok JL, Varner J, Ilaria R Jr, Cobleigh MA, Juric D, Tkaczuk KHR, Elias A, Lee A, Dakhil S, Hamilton E, Soliman H, Peluso S. O'Connell BC, et al. J Immunother Cancer. 2024 Aug 30;12(8):e009160. doi: 10.1136/jitc-2024-009160. J Immunother Cancer. 2024. PMID: 39214650 Free PMC article. Clinical Trial.
PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections.
Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, E Alexander LC, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Shepard RM, et al. Sci Transl Med. 2024 Jul 3;16(754):eadi6887. doi: 10.1126/scitranslmed.adi6887. Epub 2024 Jul 3. Sci Transl Med. 2024. PMID: 38959328 Free PMC article.
Successful control of an outbreak of Panton-Valentine leucocidin positive meticillin resistant Staphylococcus aureus in a National Burns Unit through early detection by whole genome sequencing.
Traynor R, Brennan GI, Hoban T, Dolan AM, Boyle B, O' Connell B, Shelley O, Teoh TK. Traynor R, et al. Among authors: o connell b. Infect Prev Pract. 2024 Sep 24;6(4):100400. doi: 10.1016/j.infpip.2024.100400. eCollection 2024 Dec. Infect Prev Pract. 2024. PMID: 39483423 Free PMC article.
Vitamin D, periodontitis and tooth loss in older Irish adults.
Winning L, Scarlett S, Crowe M, O'Sullivan M, Kenny RA, O'Connell B. Winning L, et al. Among authors: o connell b. Br J Nutr. 2024 Sep 18;132(4):1-9. doi: 10.1017/S000711452400148X. Online ahead of print. Br J Nutr. 2024. PMID: 39290089 Free PMC article.
Graduating European Dentist Curriculum Domain V: Research.
Field J, Dixon J, Vital S, Murphy D, O'Connell B, Davies J. Field J, et al. Among authors: o connell b. Eur J Dent Educ. 2024 Nov;28(4):1047-1051. doi: 10.1111/eje.13040. Epub 2024 Sep 14. Eur J Dent Educ. 2024. PMID: 39276377
A systems approach to managing the risk of healthcare acquired infection in an acute hospital setting supported by human factors ergonomics, data science, data governance and AI.
Ward ME, Geary U, Brennan R, Vining R, McKenna L, O'Connell B, Bergin C, Byrne D, Creagh D, Fogarty M, Healy U, McDonald G, Ebiele M, Crane M, Pham MK, Bendechache M, Bezbradica M, Liang J, Doyle B, Guilfoyle J, Shuhaiber A, McDonald N. Ward ME, et al. Among authors: o connell b. Ergonomics. 2024 Sep 8:1-19. doi: 10.1080/00140139.2024.2396527. Online ahead of print. Ergonomics. 2024. PMID: 39244770
Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample.
Sandoval-Velasco M, Dudchenko O, Rodríguez JA, Pérez Estrada C, Dehasque M, Fontsere C, Mak SST, Khan R, Contessoto VG, Oliveira Junior AB, Kalluchi A, Zubillaga Herrera BJ, Jeong J, Roy RP, Christopher I, Weisz D, Omer AD, Batra SS, Shamim MS, Durand NC, O'Connell B, Roca AL, Plikus MV, Kusliy MA, Romanenko SA, Lemskaya NA, Serdyukova NA, Modina SA, Perelman PL, Kizilova EA, Baiborodin SI, Rubtsov NB, Machol G, Rath K, Mahajan R, Kaur P, Gnirke A, Garcia-Treviño I, Coke R, Flanagan JP, Pletch K, Ruiz-Herrera A, Plotnikov V, Pavlov IS, Pavlova NI, Protopopov AV, Di Pierro M, Graphodatsky AS, Lander ES, Rowley MJ, Wolynes PG, Onuchic JN, Dalén L, Marti-Renom MA, Gilbert MTP, Aiden EL. Sandoval-Velasco M, et al. Among authors: o connell b. Cell. 2024 Jul 11;187(14):3541-3562.e51. doi: 10.1016/j.cell.2024.06.002. Cell. 2024. PMID: 38996487 Free article.
635 results